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Alkaline comet assay in liver and stomach, and micronucleus assay in bone marrow, from rats treated with 2-acetylaminofluorene, azidothymidine, cisplatin, or isobutyraldehyde.
Kraynak AR, Barnum JE, Cunningham CL, Ng A, Ykoruk BA, Bennet B, Stoffregen D, Merschman M, Freeland E, Galloway SM. Kraynak AR, et al. Among authors: ykoruk ba. Mutat Res Genet Toxicol Environ Mutagen. 2015 Jul;786-788:77-86. doi: 10.1016/j.mrgentox.2015.03.005. Epub 2015 Mar 5. Mutat Res Genet Toxicol Environ Mutagen. 2015. PMID: 26212296
Oxetane Promise Delivered: Discovery of Long-Acting IDO1 Inhibitors Suitable for Q3W Oral or Parenteral Dosing.
Li D, Sloman DL, Achab A, Zhou H, McGowan MA, White C, Gibeau C, Zhang H, Pu Q, Bharathan I, Hopkins B, Liu K, Ferguson H, Fradera X, Lesburg CA, Martinot TA, Qi J, Song ZJ, Yin J, Zhang H, Song L, Wan B, DAddio S, Solban N, Miller JR, Zamlynny B, Bass A, Freeland E, Ykoruk B, Hilliard C, Ferraro J, Zhai J, Knemeyer I, Otte KM, Vincent S, Sciammetta N, Pasternak A, Bennett DJ, Han Y. Li D, et al. J Med Chem. 2022 Apr 28;65(8):6001-6016. doi: 10.1021/acs.jmedchem.1c01670. Epub 2022 Mar 3. J Med Chem. 2022. PMID: 35239336
N-nitrosamine impurity risk assessment in pharmaceuticals: Utilizing In vivo mutation relative potency comparison to establish an acceptable intake for NTTP.
Powley MW, Sobol Z, Johnson GE, Clark RW, Dalby SM, Ykoruk BA, Galijatovic-Idrizbegovic A, Mowery MD, Escobar PA. Powley MW, et al. Among authors: ykoruk ba. Regul Toxicol Pharmacol. 2024 Sep;152:105681. doi: 10.1016/j.yrtph.2024.105681. Epub 2024 Jul 26. Regul Toxicol Pharmacol. 2024. PMID: 39067806 Free article.