Loo LH - Search Results

1

Prediction of drug-induced nephrotoxicity and injury mechanisms with human induced pluripotent stem cell-derived cells and machine learning methods.

Kandasamy K, Chuah JK, Su R, Huang P, Eng KG, Xiong S, Li Y, Chia CS, Loo LH, Zink D. Kandasamy K, et al. Among authors: loo lh. Sci Rep. 2015 Jul 27;5:12337. doi: 10.1038/srep12337. Sci Rep. 2015. PMID: 26212763 Free PMC article.

2

High-throughput imaging-based nephrotoxicity prediction for xenobiotics with diverse chemical structures.

Su R, Xiong S, Zink D, Loo LH. Su R, et al. Among authors: loo lh. Arch Toxicol. 2016 Nov;90(11):2793-2808. doi: 10.1007/s00204-015-1638-y. Epub 2015 Nov 27. Arch Toxicol. 2016. PMID: 26612367 Free PMC article.

3

High-throughput prediction of nephrotoxicity in humans.

Loo LH, Zink D. Loo LH, et al. Altern Lab Anim. 2017 Nov;45(5):241-252. doi: 10.1177/026119291704500506. Altern Lab Anim. 2017. PMID: 29112452

4

Supervised prediction of drug-induced nephrotoxicity based on interleukin-6 and -8 expression levels.

Su R, Li Y, Zink D, Loo LH. Su R, et al. Among authors: loo lh. BMC Bioinformatics. 2014;15 Suppl 16(Suppl 16):S16. doi: 10.1186/1471-2105-15-S16-S16. Epub 2014 Dec 8. BMC Bioinformatics. 2014. PMID: 25521947 Free PMC article.

5

Predicting direct hepatocyte toxicity in humans by combining high-throughput imaging of HepaRG cells and machine learning-based phenotypic profiling.

Hussain F, Basu S, Heng JJH, Loo LH, Zink D. Hussain F, et al. Among authors: loo lh. Arch Toxicol. 2020 Aug;94(8):2749-2767. doi: 10.1007/s00204-020-02778-3. Epub 2020 Jun 12. Arch Toxicol. 2020. PMID: 32533217

6

Early spatiotemporal-specific changes in intermediate signals are predictive of cytotoxic sensitivity to TNFα and co-treatments.

Loo LH, Bougen-Zhukov NM, Tan WC. Loo LH, et al. Sci Rep. 2017 Mar 8;7:43541. doi: 10.1038/srep43541. Sci Rep. 2017. PMID: 28272488 Free PMC article.

7

Building predictive in vitro pulmonary toxicity assays using high-throughput imaging and artificial intelligence.

Lee JJ, Miller JA, Basu S, Kee TV, Loo LH. Lee JJ, et al. Among authors: loo lh. Arch Toxicol. 2018 Jun;92(6):2055-2075. doi: 10.1007/s00204-018-2213-0. Epub 2018 Apr 28. Arch Toxicol. 2018. PMID: 29705884 Free PMC article.

8

A Case Study with Triazole Fungicides to Explore Practical Application of Next-Generation Hazard Assessment Methods for Human Health.

van der Ven LTM, Rorije E, Sprong RC, Zink D, Derr R, Hendriks G, Loo LH, Luijten M. van der Ven LTM, et al. Among authors: loo lh. Chem Res Toxicol. 2020 Mar 16;33(3):834-848. doi: 10.1021/acs.chemrestox.9b00484. Epub 2020 Feb 26. Chem Res Toxicol. 2020. PMID: 32041405

9

PI3K Catalytic Subunits α and β Modulate Cell Death and IL-6 Secretion Induced by Talc Particles in Human Lung Carcinoma Cells.

Bougen-Zhukov NM, Lee YY, Lee JJ, Lee P, Loo LH. Bougen-Zhukov NM, et al. Among authors: loo lh. Am J Respir Cell Mol Biol. 2020 Mar;62(3):331-341. doi: 10.1165/rcmb.2019-0050OC. Am J Respir Cell Mol Biol. 2020. PMID: 31513749

10

Image-based multivariate profiling of drug responses from single cells.

Loo LH, Wu LF, Altschuler SJ. Loo LH, et al. Nat Methods. 2007 May;4(5):445-53. doi: 10.1038/nmeth1032. Epub 2007 Apr 1. Nat Methods. 2007. PMID: 17401369

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