Roth BL - Search Results

1

Re-exploring the N-phenylpicolinamide derivatives to develop mGlu4 ligands with improved affinity and in vitro microsomal stability.

Zhang Z, Kil KE, Poutiainen P, Choi JK, Kang HJ, Huang XP, Roth BL, Brownell AL. Zhang Z, et al. Among authors: roth bl. Bioorg Med Chem Lett. 2015 Sep 15;25(18):3956-60. doi: 10.1016/j.bmcl.2015.07.031. Epub 2015 Jul 17. Bioorg Med Chem Lett. 2015. PMID: 26231155 Free PMC article.

2

1-(2,5-Dimethoxy-4-(trifluoromethyl)phenyl)-2-aminopropane: a potent serotonin 5-HT2A/2C agonist.

Nichols DE, Frescas S, Marona-Lewicka D, Huang X, Roth BL, Gudelsky GA, Nash JF. Nichols DE, et al. Among authors: roth bl. J Med Chem. 1994 Dec 9;37(25):4346-51. doi: 10.1021/jm00051a011. J Med Chem. 1994. PMID: 7996545

3

Synthesis of potent and selective serotonin 5-HT1B receptor ligands.

Huang Y, Bae SA, Roth BL, Laruelle M. Huang Y, et al. Among authors: roth bl. Bioorg Med Chem Lett. 2005 Nov 1;15(21):4786-9. doi: 10.1016/j.bmcl.2005.07.024. Bioorg Med Chem Lett. 2005. PMID: 16143528

4

Synthesis and structure-activity relationships of 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine analogues as potent, noncompetitive metabotropic glutamate receptor subtype 5 antagonists; search for cocaine medications.

Iso Y, Grajkowska E, Wroblewski JT, Davis J, Goeders NE, Johnson KM, Sanker S, Roth BL, Tueckmantel W, Kozikowski AP. Iso Y, et al. Among authors: roth bl. J Med Chem. 2006 Feb 9;49(3):1080-100. doi: 10.1021/jm050570f. J Med Chem. 2006. PMID: 16451073

5

Novel inhibitors of human histone deacetylase (HDAC) identified by QSAR modeling of known inhibitors, virtual screening, and experimental validation.

Tang H, Wang XS, Huang XP, Roth BL, Butler KV, Kozikowski AP, Jung M, Tropsha A. Tang H, et al. Among authors: roth bl. J Chem Inf Model. 2009 Feb;49(2):461-76. doi: 10.1021/ci800366f. J Chem Inf Model. 2009. PMID: 19182860

6

Parallel functional activity profiling reveals valvulopathogens are potent 5-hydroxytryptamine(2B) receptor agonists: implications for drug safety assessment.

Huang XP, Setola V, Yadav PN, Allen JA, Rogan SC, Hanson BJ, Revankar C, Robers M, Doucette C, Roth BL. Huang XP, et al. Among authors: roth bl. Mol Pharmacol. 2009 Oct;76(4):710-22. doi: 10.1124/mol.109.058057. Epub 2009 Jul 1. Mol Pharmacol. 2009. PMID: 19570945 Free PMC article.

7

N-tetrahydrothiochromenoisoxazole-1-carboxamides as selective antagonists of cloned human 5-HT2B.

Kwon YJ, Saubern S, Macdonald JM, Huang XP, Setola V, Roth BL. Kwon YJ, et al. Among authors: roth bl. Bioorg Med Chem Lett. 2010 Sep 15;20(18):5488-90. doi: 10.1016/j.bmcl.2010.07.074. Epub 2010 Jul 21. Bioorg Med Chem Lett. 2010. PMID: 20692833

8

Design, synthesis, and subtype selectivity of 3,6-disubstituted β-carbolines at Bz/GABA(A)ergic receptors. SAR and studies directed toward agents for treatment of alcohol abuse.

Yin W, Majumder S, Clayton T, Petrou S, VanLinn ML, Namjoshi OA, Ma C, Cromer BA, Roth BL, Platt DM, Cook JM. Yin W, et al. Among authors: roth bl. Bioorg Med Chem. 2010 Nov 1;18(21):7548-64. doi: 10.1016/j.bmc.2010.08.049. Epub 2010 Sep 29. Bioorg Med Chem. 2010. PMID: 20888240 Free PMC article.

9

Development, validation, and use of quantitative structure-activity relationship models of 5-hydroxytryptamine (2B) receptor ligands to identify novel receptor binders and putative valvulopathic compounds among common drugs.

Hajjo R, Grulke CM, Golbraikh A, Setola V, Huang XP, Roth BL, Tropsha A. Hajjo R, et al. Among authors: roth bl. J Med Chem. 2010 Nov 11;53(21):7573-86. doi: 10.1021/jm100600y. J Med Chem. 2010. PMID: 20958049 Free PMC article.

10

The presynaptic component of the serotonergic system is required for clozapine's efficacy.

Yadav PN, Abbas AI, Farrell MS, Setola V, Sciaky N, Huang XP, Kroeze WK, Crawford LK, Piel DA, Keiser MJ, Irwin JJ, Shoichet BK, Deneris ES, Gingrich J, Beck SG, Roth BL. Yadav PN, et al. Among authors: roth bl. Neuropsychopharmacology. 2011 Feb;36(3):638-51. doi: 10.1038/npp.2010.195. Epub 2010 Nov 3. Neuropsychopharmacology. 2011. PMID: 21048700 Free PMC article.

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