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Synthesis and structure-activity relationships of novel zwitterionic compounds as peroxisome proliferator activated receptor α/γ dual agonists with improved physicochemical properties.
Shibata Y, Kagechika K, Yamaguchi M, Yoshikawa K, Chiba K, Takano H, Akiyama C, Ono M, Nishi M, Kubo H, Kobayashi Y, Usui H. Shibata Y, et al. Chem Pharm Bull (Tokyo). 2013;61(12):1248-63. doi: 10.1248/cpb.c13-00513. Chem Pharm Bull (Tokyo). 2013. PMID: 24292787 Free article.
Discovery of DF-461, a Potent Squalene Synthase Inhibitor.
Ichikawa M, Ohtsuka M, Ohki H, Ota M, Haginoya N, Itoh M, Shibata Y, Ishigai Y, Terayama K, Kanda A, Sugita K. Ichikawa M, et al. Among authors: shibata y. ACS Med Chem Lett. 2013 Sep 4;4(10):932-6. doi: 10.1021/ml400151c. eCollection 2013 Oct 10. ACS Med Chem Lett. 2013. PMID: 24900587 Free PMC article.
Discovery of Novel Pyrido-pyridazinone Derivatives as FER Tyrosine Kinase Inhibitors with Antitumor Activity.
Taniguchi T, Inagaki H, Baba D, Yasumatsu I, Toyota A, Kaneta Y, Kiga M, Iimura S, Odagiri T, Shibata Y, Ueda K, Seo M, Shimizu H, Imaoka T, Nakayama K. Taniguchi T, et al. Among authors: shibata y. ACS Med Chem Lett. 2019 Mar 15;10(5):737-742. doi: 10.1021/acsmedchemlett.8b00631. eCollection 2019 May 9. ACS Med Chem Lett. 2019. PMID: 31097992 Free PMC article.
A novel class of cycloalkano[b]pyridines as potent and orally active opioid receptor-like 1 antagonists with minimal binding affinity to the hERG K+ channel.
Yoshizumi T, Takahashi H, Miyazoe H, Sugimoto Y, Tsujita T, Kato T, Ito H, Kawamoto H, Hirayama M, Ichikawa D, Azuma-Kanoh T, Ozaki S, Shibata Y, Tani T, Chiba M, Ishii Y, Okuda S, Tadano K, Fukuroda T, Okamoto O, Ohta H. Yoshizumi T, et al. Among authors: shibata y. J Med Chem. 2008 Jul 10;51(13):4021-9. doi: 10.1021/jm701590h. Epub 2008 Jun 7. J Med Chem. 2008. PMID: 18537234
Regulation of epigenetics and chromosome structure by human ORC2.
Su Z, Tian M, Shibata E, Shibata Y, Yang T, Wang Z, Jin F, Zang C, Dutta A. Su Z, et al. Among authors: shibata y. bioRxiv [Preprint]. 2025 Jan 15:2024.12.18.629220. doi: 10.1101/2024.12.18.629220. bioRxiv. 2025. PMID: 39829907 Free PMC article. Preprint.
Impaired oxidative phosphorylation drives primary tumor escape and metastasis.
Arner EN, Jennings EQ, Crooks DR, Ricketts CJ, Wolf MM, Cottam MA, Fisher-Gupta EL, Lang M, Maio N, Shibata Y, Krystofiak ES, Vlach LM, Hatem Z, Blatt AM, Heintzman DR, Sewell AE, Hathaway ES, Steiner KK, Ye X, Schaefer S, Bacigalupa ZA, Linehan WM, Beckermann KE, Mason FM, Idrees K, Rathmell WK, Rathmell JC. Arner EN, et al. Among authors: shibata y. bioRxiv [Preprint]. 2025 Jan 9:2025.01.08.631936. doi: 10.1101/2025.01.08.631936. bioRxiv. 2025. PMID: 39829901 Free PMC article. Preprint.
2,800 results