Burk O - Search Results

1

Variability in hepatic expression of organic anion transporter 7/SLC22A9, a novel pravastatin uptake transporter: impact of genetic and regulatory factors.

Emami Riedmaier A, Burk O, van Eijck BA, Schaeffeler E, Klein K, Fehr S, Biskup S, Müller S, Winter S, Zanger UM, Schwab M, Nies AT. Emami Riedmaier A, et al. Among authors: burk o. Pharmacogenomics J. 2016 Aug;16(4):341-51. doi: 10.1038/tpj.2015.55. Epub 2015 Aug 4. Pharmacogenomics J. 2016. PMID: 26239079

2

Expression of organic cation transporters OCT1 (SLC22A1) and OCT3 (SLC22A3) is affected by genetic factors and cholestasis in human liver.

Nies AT, Koepsell H, Winter S, Burk O, Klein K, Kerb R, Zanger UM, Keppler D, Schwab M, Schaeffeler E. Nies AT, et al. Among authors: burk o. Hepatology. 2009 Oct;50(4):1227-40. doi: 10.1002/hep.23103. Hepatology. 2009. PMID: 19591196

3

Genetics is a major determinant of expression of the human hepatic uptake transporter OATP1B1, but not of OATP1B3 and OATP2B1.

Nies AT, Niemi M, Burk O, Winter S, Zanger UM, Stieger B, Schwab M, Schaeffeler E. Nies AT, et al. Among authors: burk o. Genome Med. 2013 Jan 11;5(1):1. doi: 10.1186/gm405. eCollection 2013. Genome Med. 2013. PMID: 23311897 Free PMC article.

4

Human sterol regulatory element-binding protein 1a contributes significantly to hepatic lipogenic gene expression.

Bitter A, Nüssler AK, Thasler WE, Klein K, Zanger UM, Schwab M, Burk O. Bitter A, et al. Among authors: burk o. Cell Physiol Biochem. 2015;35(2):803-15. doi: 10.1159/000369739. Epub 2015 Jan 30. Cell Physiol Biochem. 2015. PMID: 25634759 Free article.

5

Sex is a major determinant of CYP3A4 expression in human liver.

Wolbold R, Klein K, Burk O, Nüssler AK, Neuhaus P, Eichelbaum M, Schwab M, Zanger UM. Wolbold R, et al. Among authors: burk o. Hepatology. 2003 Oct;38(4):978-88. doi: 10.1053/jhep.2003.50393. Hepatology. 2003. PMID: 14512885

6

Molecular mechanism of basal CYP3A4 regulation by hepatocyte nuclear factor 4alpha: evidence for direct regulation in the intestine.

Tegude H, Schnabel A, Zanger UM, Klein K, Eichelbaum M, Burk O. Tegude H, et al. Among authors: burk o. Drug Metab Dispos. 2007 Jun;35(6):946-54. doi: 10.1124/dmd.106.013565. Epub 2007 Mar 7. Drug Metab Dispos. 2007. PMID: 17344340

7

PXR variants and artemisinin use in Vietnamese subjects: frequency distribution and impact on the interindividual variability of CYP3A induction by artemisinin.

Piedade R, Schaeffeler E, Winter S, Asimus S, Schwab M, Ashton M, Burk O, Gil JP. Piedade R, et al. Among authors: burk o. Antimicrob Agents Chemother. 2012 Apr;56(4):2153-7. doi: 10.1128/AAC.06009-11. Epub 2012 Jan 17. Antimicrob Agents Chemother. 2012. PMID: 22252826 Free PMC article.

8

Direct transcriptional regulation of human hepatic cytochrome P450 3A4 (CYP3A4) by peroxisome proliferator-activated receptor alpha (PPARα).

Thomas M, Burk O, Klumpp B, Kandel BA, Damm G, Weiss TS, Klein K, Schwab M, Zanger UM. Thomas M, et al. Among authors: burk o. Mol Pharmacol. 2013 Mar;83(3):709-18. doi: 10.1124/mol.112.082503. Epub 2013 Jan 7. Mol Pharmacol. 2013. PMID: 23295386

9

Pregnane X receptor activation and silencing promote steatosis of human hepatic cells by distinct lipogenic mechanisms.

Bitter A, Rümmele P, Klein K, Kandel BA, Rieger JK, Nüssler AK, Zanger UM, Trauner M, Schwab M, Burk O. Bitter A, et al. Among authors: burk o. Arch Toxicol. 2015 Nov;89(11):2089-103. doi: 10.1007/s00204-014-1348-x. Epub 2014 Sep 3. Arch Toxicol. 2015. PMID: 25182422

10

Genomewide comparison of the inducible transcriptomes of nuclear receptors CAR, PXR and PPARα in primary human hepatocytes.

Kandel BA, Thomas M, Winter S, Damm G, Seehofer D, Burk O, Schwab M, Zanger UM. Kandel BA, et al. Among authors: burk o. Biochim Biophys Acta. 2016 Sep;1859(9):1218-1227. doi: 10.1016/j.bbagrm.2016.03.007. Epub 2016 Mar 17. Biochim Biophys Acta. 2016. PMID: 26994748

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