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Establishing best practise in the application of expert review of mutagenicity under ICH M7.
Barber C, Amberg A, Custer L, Dobo KL, Glowienke S, Van Gompel J, Gutsell S, Harvey J, Honma M, Kenyon MO, Kruhlak N, Muster W, Stavitskaya L, Teasdale A, Vessey J, Wichard J. Barber C, et al. Among authors: kruhlak n. Regul Toxicol Pharmacol. 2015 Oct;73(1):367-77. doi: 10.1016/j.yrtph.2015.07.018. Epub 2015 Aug 4. Regul Toxicol Pharmacol. 2015. PMID: 26248005
An analysis of genetic toxicity, reproductive and developmental toxicity, and carcinogenicity data: II. Identification of genotoxicants, reprotoxicants, and carcinogens using in silico methods.
Matthews EJ, Kruhlak NL, Cimino MC, Benz RD, Contrera JF. Matthews EJ, et al. Regul Toxicol Pharmacol. 2006 Mar;44(2):97-110. doi: 10.1016/j.yrtph.2005.10.004. Epub 2005 Dec 13. Regul Toxicol Pharmacol. 2006. PMID: 16352383
We constructed 21 modules using the MC4PC program including 13 of 14 (11 genetox and 3 reprotox) tests that we found correlated with results of rodent carcinogenicity bioassays (rcbioassays) [Matthews, E.J., Kruhlak, N.L., Cimino, M.C., Benz, R.D., Contrera, J.F., 2 …
We constructed 21 modules using the MC4PC program including 13 of 14 (11 genetox and 3 reprotox) tests that we found correlated with results …
Identification of structure-activity relationships for adverse effects of pharmaceuticals in humans: Part C: use of QSAR and an expert system for the estimation of the mechanism of action of drug-induced hepatobiliary and urinary tract toxicities.
Matthews EJ, Kruhlak NL, Benz RD, Aragonés Sabaté D, Marchant CA, Contrera JF. Matthews EJ, et al. Regul Toxicol Pharmacol. 2009 Jun;54(1):43-65. doi: 10.1016/j.yrtph.2009.01.007. Regul Toxicol Pharmacol. 2009. PMID: 19422100
48 results