Ellisdon AM - Search Results

1

Detection and Quantification of Intracellular Signaling Using FRET-Based Biosensors and High Content Imaging.

Halls ML, Poole DP, Ellisdon AM, Nowell CJ, Canals M. Halls ML, et al. Among authors: ellisdon am. Methods Mol Biol. 2015;1335:131-61. doi: 10.1007/978-1-4939-2914-6_10. Methods Mol Biol. 2015. PMID: 26260599

2

The Phosphatidylinositol (3,4,5)-Trisphosphate-dependent Rac Exchanger 1·Ras-related C3 Botulinum Toxin Substrate 1 (P-Rex1·Rac1) Complex Reveals the Basis of Rac1 Activation in Breast Cancer Cells.

Lucato CM, Halls ML, Ooms LM, Liu HJ, Mitchell CA, Whisstock JC, Ellisdon AM. Lucato CM, et al. Among authors: ellisdon am. J Biol Chem. 2015 Aug 21;290(34):20827-20840. doi: 10.1074/jbc.M115.660456. Epub 2015 Jun 24. J Biol Chem. 2015. PMID: 26112412 Free PMC article.

3

Compartmentalization of GPCR signalling controls unique cellular responses.

Ellisdon AM, Halls ML. Ellisdon AM, et al. Biochem Soc Trans. 2016 Apr 15;44(2):562-7. doi: 10.1042/BST20150236. Biochem Soc Trans. 2016. PMID: 27068970 Review.

4

Amyloidogenicity at a Distance: How Distal Protein Regions Modulate Aggregation in Disease.

Lucato CM, Lupton CJ, Halls ML, Ellisdon AM. Lucato CM, et al. Among authors: ellisdon am. J Mol Biol. 2017 May 5;429(9):1289-1304. doi: 10.1016/j.jmb.2017.03.021. Epub 2017 Mar 22. J Mol Biol. 2017. PMID: 28342736 Review.

5

Preassembled GPCR signaling complexes mediate distinct cellular responses to ultralow ligand concentrations.

Civciristov S, Ellisdon AM, Suderman R, Pon CK, Evans BA, Kleifeld O, Charlton SJ, Hlavacek WS, Canals M, Halls ML. Civciristov S, et al. Among authors: ellisdon am. Sci Signal. 2018 Oct 9;11(551):eaan1188. doi: 10.1126/scisignal.aan1188. Sci Signal. 2018. PMID: 30301787 Free PMC article.

6

Ligand-dependent spatiotemporal signaling profiles of the μ-opioid receptor are controlled by distinct protein-interaction networks.

Civciristov S, Huang C, Liu B, Marquez EA, Gondin AB, Schittenhelm RB, Ellisdon AM, Canals M, Halls ML. Civciristov S, et al. Among authors: ellisdon am. J Biol Chem. 2019 Nov 1;294(44):16198-16213. doi: 10.1074/jbc.RA119.008685. Epub 2019 Sep 12. J Biol Chem. 2019. PMID: 31515267 Free PMC article.

7

Structural analysis of the PTEN:P-Rex2 signaling complex reveals how cancer-associated mutations coordinate to hyperactivate Rac1.

D'Andrea L, Lucato CM, Marquez EA, Chang YG, Civciristov S, Mastos C, Lupton CJ, Huang C, Elmlund H, Schittenhelm RB, Mitchell CA, Whisstock JC, Halls ML, Ellisdon AM. D'Andrea L, et al. Among authors: ellisdon am. Sci Signal. 2021 May 4;14(681):eabc4078. doi: 10.1126/scisignal.abc4078. Sci Signal. 2021. PMID: 33947796

8

The cryo-EM structure of the human neurofibromin dimer reveals the molecular basis for neurofibromatosis type 1.

Lupton CJ, Bayly-Jones C, D'Andrea L, Huang C, Schittenhelm RB, Venugopal H, Whisstock JC, Halls ML, Ellisdon AM. Lupton CJ, et al. Among authors: ellisdon am. Nat Struct Mol Biol. 2021 Dec;28(12):982-988. doi: 10.1038/s41594-021-00687-2. Epub 2021 Dec 9. Nat Struct Mol Biol. 2021. PMID: 34887559

9

Structure of the metastatic factor P-Rex1 reveals a two-layered autoinhibitory mechanism.

Chang YG, Lupton CJ, Bayly-Jones C, Keen AC, D'Andrea L, Lucato CM, Steele JR, Venugopal H, Schittenhelm RB, Whisstock JC, Halls ML, Ellisdon AM. Chang YG, et al. Among authors: ellisdon am. Nat Struct Mol Biol. 2022 Aug;29(8):767-773. doi: 10.1038/s41594-022-00804-9. Epub 2022 Jul 21. Nat Struct Mol Biol. 2022. PMID: 35864164 Free PMC article.

10

LYCHOS is a human hybrid of a plant-like PIN transporter and a GPCR.

Bayly-Jones C, Lupton CJ, Keen AC, Dong S, Mastos C, Luo W, Qian C, Jones GD, Venugopal H, Chang YG, Clarke RJ, Halls ML, Ellisdon AM. Bayly-Jones C, et al. Among authors: ellisdon am. Nature. 2024 Oct;634(8036):1238-1244. doi: 10.1038/s41586-024-08012-9. Epub 2024 Oct 2. Nature. 2024. PMID: 39358511 Free PMC article.

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