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Page 1
Antibodies targeting human IL1RAP (IL1R3) show therapeutic effects in xenograft models of acute myeloid leukemia.
Ågerstam H, Karlsson C, Hansen N, Sandén C, Askmyr M, von Palffy S, Högberg C, Rissler M, Wunderlich M, Juliusson G, Richter J, Sjöström K, Bhatia R, Mulloy JC, Järås M, Fioretos T. Ågerstam H, et al. Among authors: von palffy s. Proc Natl Acad Sci U S A. 2015 Aug 25;112(34):10786-91. doi: 10.1073/pnas.1422749112. Epub 2015 Aug 10. Proc Natl Acad Sci U S A. 2015. PMID: 26261316 Free PMC article.
Modeling chronic myeloid leukemia in immunodeficient mice reveals expansion of aberrant mast cells and accumulation of pre-B cells.
Askmyr M, Ågerstam H, Lilljebjörn H, Hansen N, Karlsson C, von Palffy S, Landberg N, Högberg C, Lassen C, Rissler M, Richter J, Ehinger M, Järås M, Fioretos T. Askmyr M, et al. Among authors: von palffy s. Blood Cancer J. 2014 Dec 12;4(12):e269. doi: 10.1038/bcj.2014.89. Blood Cancer J. 2014. PMID: 25501026 Free PMC article.
Identification of ETV6-RUNX1-like and DUX4-rearranged subtypes in paediatric B-cell precursor acute lymphoblastic leukaemia.
Lilljebjörn H, Henningsson R, Hyrenius-Wittsten A, Olsson L, Orsmark-Pietras C, von Palffy S, Askmyr M, Rissler M, Schrappe M, Cario G, Castor A, Pronk CJ, Behrendtz M, Mitelman F, Johansson B, Paulsson K, Andersson AK, Fontes M, Fioretos T. Lilljebjörn H, et al. Among authors: von palffy s. Nat Commun. 2016 Jun 6;7:11790. doi: 10.1038/ncomms11790. Nat Commun. 2016. PMID: 27265895 Free PMC article.
IL1RAP antibodies block IL-1-induced expansion of candidate CML stem cells and mediate cell killing in xenograft models.
Ågerstam H, Hansen N, von Palffy S, Sandén C, Reckzeh K, Karlsson C, Lilljebjörn H, Landberg N, Askmyr M, Högberg C, Rissler M, Porkka K, Wadenvik H, Mustjoki S, Richter J, Järås M, Fioretos T. Ågerstam H, et al. Among authors: von palffy s. Blood. 2016 Dec 8;128(23):2683-2693. doi: 10.1182/blood-2015-11-679985. Epub 2016 Sep 12. Blood. 2016. PMID: 27621309 Free article.
CD36 defines primitive chronic myeloid leukemia cells less responsive to imatinib but vulnerable to antibody-based therapeutic targeting.
Landberg N, von Palffy S, Askmyr M, Lilljebjörn H, Sandén C, Rissler M, Mustjoki S, Hjorth-Hansen H, Richter J, Ågerstam H, Järås M, Fioretos T. Landberg N, et al. Among authors: von palffy s. Haematologica. 2018 Mar;103(3):447-455. doi: 10.3324/haematol.2017.169946. Epub 2017 Dec 28. Haematologica. 2018. PMID: 29284680 Free PMC article.
A high-content cytokine screen identifies myostatin propeptide as a positive regulator of primitive chronic myeloid leukemia cells.
von Palffy S, Landberg N, Sandén C, Zacharaki D, Shah M, Nakamichi N, Hansen N, Askmyr M, Lilljebjörn H, Rissler M, Karlsson C, Scheding S, Richter J, Eaves CJ, Bhatia R, Järås M, Fioretos T. von Palffy S, et al. Haematologica. 2020 Aug;105(8):2095-2104. doi: 10.3324/haematol.2019.220434. Epub 2019 Oct 3. Haematologica. 2020. PMID: 31582541 Free PMC article.
Clonal competition within complex evolutionary hierarchies shapes AML over time.
Sandén C, Lilljebjörn H, Orsmark Pietras C, Henningsson R, Saba KH, Landberg N, Thorsson H, von Palffy S, Peña-Martinez P, Högberg C, Rissler M, Gisselsson D, Lazarevic V, Juliusson G, Ågerstam H, Fioretos T. Sandén C, et al. Among authors: von palffy s. Nat Commun. 2020 Feb 5;11(1):579. doi: 10.1038/s41467-019-14106-0. Nat Commun. 2020. PMID: 32024830 Free PMC article.
The complement receptor C3AR constitutes a novel therapeutic target in NPM1-mutated AML.
von Palffy S, Thorsson H, Peña-Martínez P, Puente-Moncada N, Sandén C, Blom AM, Henningsson R, Juliusson G, King B, Landberg N, Lazarevic V, Orsmark-Pietras C, Rissler M, Rissler V, Ågerstam H, Järås M, Lilljebjörn H, Fioretos T. von Palffy S, et al. Blood Adv. 2023 Apr 11;7(7):1204-1218. doi: 10.1182/bloodadvances.2022007682. Blood Adv. 2023. PMID: 36383712 Free PMC article.