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Collective Synthesis of Sarpagine and Macroline Alkaloid-Inspired Compounds.
Aoyama H, Davies C, Liu J, Pahl A, Kirchhoff JL, Scheel R, Sievers S, Strohmann C, Grigalunas M, Waldmann H. Aoyama H, et al. Among authors: grigalunas m. Chemistry. 2024 Jan 22;30(5):e202303027. doi: 10.1002/chem.202303027. Epub 2023 Nov 29. Chemistry. 2024. PMID: 37755456
A highly enantioselective intramolecular 1,3-dipolar cycloaddition yields novel pseudo-natural product inhibitors of the Hedgehog signalling pathway.
Liu J, Zhang R, Mallick S, Patil S, Wientjens C, Flegel J, Krupp A, Strohmann C, Grassin C, Merten C, Pahl A, Grigalunas M, Waldmann H. Liu J, et al. Among authors: grigalunas m. Chem Sci. 2023 Jun 21;14(29):7936-7943. doi: 10.1039/d3sc01240a. eCollection 2023 Jul 26. Chem Sci. 2023. PMID: 37502335 Free PMC article.
The Time and Place for Nature in Drug Discovery.
Young RJ, Flitsch SL, Grigalunas M, Leeson PD, Quinn RJ, Turner NJ, Waldmann H. Young RJ, et al. Among authors: grigalunas m. JACS Au. 2022 Oct 14;2(11):2400-2416. doi: 10.1021/jacsau.2c00415. eCollection 2022 Nov 28. JACS Au. 2022. PMID: 36465532 Free PMC article. Review.
2-Hydroxypropyl-β-cyclodextrin is the active component in a triple combination formulation for treatment of Niemann-Pick C1 disease.
Davidson J, Molitor E, Moores S, Gale SE, Subramanian K, Jiang X, Sidhu R, Kell P, Zhang J, Fujiwara H, Davidson C, Helquist P, Melancon BJ, Grigalunas M, Liu G, Salahi F, Wiest O, Xu X, Porter FD, Pipalia NH, Cruz DL, Holson EB, Schaffer JE, Walkley SU, Maxfield FR, Ory DS. Davidson J, et al. Among authors: grigalunas m. Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Oct;1864(10):1545-1561. doi: 10.1016/j.bbalip.2019.04.011. Epub 2019 Apr 30. Biochim Biophys Acta Mol Cell Biol Lipids. 2019. PMID: 31051283 Free PMC article.
Design, Synthesis, and Evaluation of a Luminescent Cholesterol Mimic.
Work EM, Ferraudi G, Kiefer L, Liu G, Grigalunas M, Bhardwaj A, Kaur R, Dempsey JM, Wüstner D, Helquist P, Wiest O. Work EM, et al. Among authors: grigalunas m. J Org Chem. 2021 Jan 15;86(2):1612-1621. doi: 10.1021/acs.joc.0c02460. Epub 2020 Dec 28. J Org Chem. 2021. PMID: 33369429 Free PMC article.
23 results