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Page 1
Discovery of Triazole CYP11B2 Inhibitors with in Vivo Activity in Rhesus Monkeys.
Hoyt SB, Petrilli W, London C, Liang GB, Tata J, Hu Q, Yin L, van Koppen CJ, Hartmann RW, Struthers M, Wisniewski T, Ren N, Bopp C, Sok A, Cai TQ, Stribling S, Pai LY, Ma X, Metzger J, Verras A, McMasters D, Chen Q, Tung E, Tang W, Salituro G, Buist N, Clemas J, Zhou G, Gibson J, Maxwell CA, Lassman M, McLaughlin T, Castro-Perez J, Szeto D, Forrest G, Hajdu R, Rosenbach M, Xiong Y. Hoyt SB, et al. Among authors: hu q. ACS Med Chem Lett. 2015 Jul 17;6(8):861-5. doi: 10.1021/acsmedchemlett.5b00048. eCollection 2015 Aug 13. ACS Med Chem Lett. 2015. PMID: 26288685 Free PMC article.
Synthesis, biological evaluation and molecular modelling studies of methyleneimidazole substituted biaryls as inhibitors of human 17alpha-hydroxylase-17,20-lyase (CYP17). Part I: Heterocyclic modifications of the core structure.
Jagusch C, Negri M, Hille UE, Hu Q, Bartels M, Jahn-Hoffmann K, Pinto-Bazurco Mendieta MA, Rodenwaldt B, Müller-Vieira U, Schmidt D, Lauterbach T, Recanatini M, Cavalli A, Hartmann RW. Jagusch C, et al. Among authors: hu q. Bioorg Med Chem. 2008 Feb 15;16(4):1992-2010. doi: 10.1016/j.bmc.2007.10.094. Epub 2007 Nov 4. Bioorg Med Chem. 2008. PMID: 18061460
Synthesis, biological evaluation, and molecular modeling studies of methylene imidazole substituted biaryls as inhibitors of human 17alpha-hydroxylase-17,20-lyase (CYP17)--part II: Core rigidification and influence of substituents at the methylene bridge.
Hu Q, Negri M, Jahn-Hoffmann K, Zhuang Y, Olgen S, Bartels M, Müller-Vieira U, Lauterbach T, Hartmann RW. Hu Q, et al. Bioorg Med Chem. 2008 Aug 15;16(16):7715-27. doi: 10.1016/j.bmc.2008.07.011. Epub 2008 Jul 9. Bioorg Med Chem. 2008. PMID: 18674917
CYP17 inhibitors. Annulations of additional rings in methylene imidazole substituted biphenyls: synthesis, biological evaluation and molecular modelling.
Pinto-Bazurco Mendieta MA, Negri M, Hu Q, Hille UE, Jagusch C, Jahn-Hoffmann K, Müller-Vieira U, Schmidt D, Lauterbach T, Hartmann RW. Pinto-Bazurco Mendieta MA, et al. Among authors: hu q. Arch Pharm (Weinheim). 2008 Oct;341(10):597-609. doi: 10.1002/ardp.200700251. Arch Pharm (Weinheim). 2008. PMID: 18720339
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