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Muscle inactivation of mTOR causes metabolic and dystrophin defects leading to severe myopathy.
Risson V, Mazelin L, Roceri M, Sanchez H, Moncollin V, Corneloup C, Richard-Bulteau H, Vignaud A, Baas D, Defour A, Freyssenet D, Tanti JF, Le-Marchand-Brustel Y, Ferrier B, Conjard-Duplany A, Romanino K, Bauché S, Hantaï D, Mueller M, Kozma SC, Thomas G, Rüegg MA, Ferry A, Pende M, Bigard X, Koulmann N, Schaeffer L, Gangloff YG. Risson V, et al. J Cell Biol. 2009 Dec 14;187(6):859-74. doi: 10.1083/jcb.200903131. J Cell Biol. 2009. PMID: 20008564 Free PMC article.
Downregulation of Akt/mammalian target of rapamycin pathway in skeletal muscle is associated with increased REDD1 expression in response to chronic hypoxia.
Favier FB, Costes F, Defour A, Bonnefoy R, Lefai E, Baugé S, Peinnequin A, Benoit H, Freyssenet D. Favier FB, et al. Am J Physiol Regul Integr Comp Physiol. 2010 Jun;298(6):R1659-66. doi: 10.1152/ajpregu.00550.2009. Epub 2010 Mar 17. Am J Physiol Regul Integr Comp Physiol. 2010. PMID: 20237300 Free article.
67 results