Schmitz J - Search Results

1

Design, characterization and cellular uptake studies of fluorescence-labeled prototypic cathepsin inhibitors.

Kohl F, Schmitz J, Furtmann N, Schulz-Fincke AC, Mertens MD, Küppers J, Benkhoff M, Tobiasch E, Bartz U, Bajorath J, Stirnberg M, Gütschow M. Kohl F, et al. Among authors: schmitz j. Org Biomol Chem. 2015 Nov 7;13(41):10310-23. doi: 10.1039/c5ob01613d. Org Biomol Chem. 2015. PMID: 26307943

2

Selective nitrile inhibitors to modulate the proteolytic synergism of cathepsins S and F.

Frizler M, Schmitz J, Schulz-Fincke AC, Gütschow M. Frizler M, et al. Among authors: schmitz j. J Med Chem. 2012 Jun 28;55(12):5982-6. doi: 10.1021/jm300734k. Epub 2012 Jun 20. J Med Chem. 2012. PMID: 22686657

3

A coumarin-labeled vinyl sulfone as tripeptidomimetic activity-based probe for cysteine cathepsins.

Mertens MD, Schmitz J, Horn M, Furtmann N, Bajorath J, Mareš M, Gütschow M. Mertens MD, et al. Among authors: schmitz j. Chembiochem. 2014 May 5;15(7):955-9. doi: 10.1002/cbic.201300806. Epub 2014 Mar 19. Chembiochem. 2014. PMID: 24648212

4

Active Site Mapping of Human Cathepsin F with Dipeptide Nitrile Inhibitors.

Schmitz J, Furtmann N, Ponert M, Frizler M, Löser R, Bartz U, Bajorath J, Gütschow M. Schmitz J, et al. ChemMedChem. 2015 Aug;10(8):1365-77. doi: 10.1002/cmdc.201500151. Epub 2015 Jun 26. ChemMedChem. 2015. PMID: 26119278

5

Synthesis and kinetic evaluation of ethyl acrylate and vinyl sulfone derived inhibitors for human cysteine cathepsins.

Breuer C, Lemke C, Schmitz J, Bartz U, Gütschow M. Breuer C, et al. Among authors: schmitz j. Bioorg Med Chem Lett. 2018 Jun 15;28(11):2008-2012. doi: 10.1016/j.bmcl.2018.05.005. Epub 2018 May 4. Bioorg Med Chem Lett. 2018. PMID: 29748052

6

Cathepsin B: Active site mapping with peptidic substrates and inhibitors.

Schmitz J, Gilberg E, Löser R, Bajorath J, Bartz U, Gütschow M. Schmitz J, et al. Bioorg Med Chem. 2019 Jan 1;27(1):1-15. doi: 10.1016/j.bmc.2018.10.017. Epub 2018 Oct 19. Bioorg Med Chem. 2019. PMID: 30473362 Review.

7

An access to aza-Freidinger lactams and E-locked analogs.

Ottersbach PA, Schmitz J, Schnakenburg G, Gütschow M. Ottersbach PA, et al. Among authors: schmitz j. Org Lett. 2013 Feb 1;15(3):448-51. doi: 10.1021/ol3030583. Epub 2013 Jan 15. Org Lett. 2013. PMID: 23320486

8

3-Cyano-3-aza-β-amino Acid Derivatives as Inhibitors of Human Cysteine Cathepsins.

Schmitz J, Beckmann AM, Dudic A, Li T, Sellier R, Bartz U, Gütschow M. Schmitz J, et al. ACS Med Chem Lett. 2014 Aug 11;5(10):1076-81. doi: 10.1021/ml500238q. eCollection 2014 Oct 9. ACS Med Chem Lett. 2014. PMID: 25313316 Free PMC article.

9

Cathepsin B Inhibitors: Combining Dipeptide Nitriles with an Occluding Loop Recognition Element by Click Chemistry.

Schmitz J, Li T, Bartz U, Gütschow M. Schmitz J, et al. ACS Med Chem Lett. 2015 Dec 28;7(3):211-6. doi: 10.1021/acsmedchemlett.5b00474. eCollection 2016 Mar 10. ACS Med Chem Lett. 2015. PMID: 26985300 Free PMC article.

10

Evaluation of dipeptide nitriles as inhibitors of rhodesain, a major cysteine protease of Trypanosoma brucei.

Schirmeister T, Schmitz J, Jung S, Schmenger T, Krauth-Siegel RL, Gütschow M. Schirmeister T, et al. Among authors: schmitz j. Bioorg Med Chem Lett. 2017 Jan 1;27(1):45-50. doi: 10.1016/j.bmcl.2016.11.036. Epub 2016 Nov 15. Bioorg Med Chem Lett. 2017. PMID: 27890381

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