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G protein coupling and second messenger generation are indispensable for metalloprotease-dependent, heparin-binding epidermal growth factor shedding through angiotensin II type-1 receptor.
Mifune M, Ohtsu H, Suzuki H, Nakashima H, Brailoiu E, Dun NJ, Frank GD, Inagami T, Higashiyama S, Thomas WG, Eckhart AD, Dempsey PJ, Eguchi S. Mifune M, et al. Among authors: eguchi s. J Biol Chem. 2005 Jul 15;280(28):26592-9. doi: 10.1074/jbc.M502906200. Epub 2005 May 19. J Biol Chem. 2005. PMID: 15905175 Free article.
AT1 receptor signaling pathways in the cardiovascular system.
Kawai T, Forrester SJ, O'Brien S, Baggett A, Rizzo V, Eguchi S. Kawai T, et al. Among authors: eguchi s. Pharmacol Res. 2017 Nov;125(Pt A):4-13. doi: 10.1016/j.phrs.2017.05.008. Epub 2017 May 17. Pharmacol Res. 2017. PMID: 28527699 Free PMC article. Review.
BRET-based assay to monitor EGFR transactivation by the AT1R reveals Gq/11 protein-independent activation and AT1R-EGFR complexes.
O'Brien SL, Johnstone EKM, Devost D, Conroy J, Reichelt ME, Purdue BW, Ayoub MA, Kawai T, Inoue A, Eguchi S, Hébert TE, Pfleger KDG, Thomas WG. O'Brien SL, et al. Among authors: eguchi s. Biochem Pharmacol. 2018 Dec;158:232-242. doi: 10.1016/j.bcp.2018.10.017. Epub 2018 Oct 19. Biochem Pharmacol. 2018. PMID: 30347205 Free PMC article.
THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: G protein-coupled receptors.
Alexander SPH, Christopoulos A, Davenport AP, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. Alexander SPH, et al. Br J Pharmacol. 2019 Dec;176 Suppl 1(Suppl 1):S21-S141. doi: 10.1111/bph.14748. Br J Pharmacol. 2019. PMID: 31710717 Free PMC article. Review.
1,592 results