Fairlie WD - Search Results

1

α/β-Peptide Foldamers Targeting Intracellular Protein-Protein Interactions with Activity in Living Cells.

Checco JW, Lee EF, Evangelista M, Sleebs NJ, Rogers K, Pettikiriarachchi A, Kershaw NJ, Eddinger GA, Belair DG, Wilson JL, Eller CH, Raines RT, Murphy WL, Smith BJ, Gellman SH, Fairlie WD. Checco JW, et al. Among authors: fairlie wd. J Am Chem Soc. 2015 Sep 9;137(35):11365-75. doi: 10.1021/jacs.5b05896. Epub 2015 Aug 28. J Am Chem Soc. 2015. PMID: 26317395 Free PMC article.

2

Affinity maturation of leukemia inhibitory factor and conversion to potent antagonists of signaling.

Fairlie WD, Uboldi AD, McCoubrie JE, Wang CC, Lee EF, Yao S, De Souza DP, Mifsud S, Metcalf D, Nicola NA, Norton RS, Baca M. Fairlie WD, et al. J Biol Chem. 2004 Jan 16;279(3):2125-34. doi: 10.1074/jbc.M310103200. Epub 2003 Oct 29. J Biol Chem. 2004. PMID: 14585833 Free article.

3

A family of leukemia inhibitory factor-binding peptides that can act as antagonists when conjugated to poly(ethylene glycol).

Fairlie WD, Uboldi AD, Hemmings GJ, Smith BJ, Martin HM, Morgan PO, Baca M. Fairlie WD, et al. Biochemistry. 2003 Nov 18;42(45):13193-201. doi: 10.1021/bi035303v. Biochemistry. 2003. PMID: 14609330

4

(alpha/beta+alpha)-peptide antagonists of BH3 domain/Bcl-x(L) recognition: toward general strategies for foldamer-based inhibition of protein-protein interactions.

Sadowsky JD, Fairlie WD, Hadley EB, Lee HS, Umezawa N, Nikolovska-Coleska Z, Wang S, Huang DC, Tomita Y, Gellman SH. Sadowsky JD, et al. Among authors: fairlie wd. J Am Chem Soc. 2007 Jan 10;129(1):139-54. doi: 10.1021/ja0662523. J Am Chem Soc. 2007. PMID: 17199293

5

Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak.

Willis SN, Fletcher JI, Kaufmann T, van Delft MF, Chen L, Czabotar PE, Ierino H, Lee EF, Fairlie WD, Bouillet P, Strasser A, Kluck RM, Adams JM, Huang DC. Willis SN, et al. Among authors: fairlie wd. Science. 2007 Feb 9;315(5813):856-9. doi: 10.1126/science.1133289. Science. 2007. PMID: 17289999

6

A structural viral mimic of prosurvival Bcl-2: a pivotal role for sequestering proapoptotic Bax and Bak.

Kvansakul M, van Delft MF, Lee EF, Gulbis JM, Fairlie WD, Huang DC, Colman PM. Kvansakul M, et al. Among authors: fairlie wd. Mol Cell. 2007 Mar 23;25(6):933-42. doi: 10.1016/j.molcel.2007.02.004. Mol Cell. 2007. PMID: 17386268 Free article.

7

Structural insights into the degradation of Mcl-1 induced by BH3 domains.

Czabotar PE, Lee EF, van Delft MF, Day CL, Smith BJ, Huang DC, Fairlie WD, Hinds MG, Colman PM. Czabotar PE, et al. Among authors: fairlie wd. Proc Natl Acad Sci U S A. 2007 Apr 10;104(15):6217-22. doi: 10.1073/pnas.0701297104. Epub 2007 Mar 27. Proc Natl Acad Sci U S A. 2007. PMID: 17389404 Free PMC article.

8

Crystal structure of ABT-737 complexed with Bcl-xL: implications for selectivity of antagonists of the Bcl-2 family.

Lee EF, Czabotar PE, Smith BJ, Deshayes K, Zobel K, Colman PM, Fairlie WD. Lee EF, et al. Among authors: fairlie wd. Cell Death Differ. 2007 Sep;14(9):1711-3. doi: 10.1038/sj.cdd.4402178. Epub 2007 Jun 15. Cell Death Differ. 2007. PMID: 17572662 No abstract available.

9

A novel BH3 ligand that selectively targets Mcl-1 reveals that apoptosis can proceed without Mcl-1 degradation.

Lee EF, Czabotar PE, van Delft MF, Michalak EM, Boyle MJ, Willis SN, Puthalakath H, Bouillet P, Colman PM, Huang DC, Fairlie WD. Lee EF, et al. Among authors: fairlie wd. J Cell Biol. 2008 Jan 28;180(2):341-55. doi: 10.1083/jcb.200708096. Epub 2008 Jan 21. J Cell Biol. 2008. PMID: 18209102 Free PMC article.

10

EGL-1 BH3 mutants reveal the importance of protein levels and target affinity for cell-killing potency.

Lee EF, Chen L, Yang H, Colman PM, Huang DC, Fairlie WD. Lee EF, et al. Among authors: fairlie wd. Cell Death Differ. 2008 Oct;15(10):1609-18. doi: 10.1038/cdd.2008.86. Epub 2008 Jun 20. Cell Death Differ. 2008. PMID: 18566606

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