Thummel KE - Search Results

1

Interindividual variability of CYP2C19-catalyzed drug metabolism due to differences in gene diplotypes and cytochrome P450 oxidoreductase content.

Shirasaka Y, Chaudhry AS, McDonald M, Prasad B, Wong T, Calamia JC, Fohner A, Thornton TA, Isoherranen N, Unadkat JD, Rettie AE, Schuetz EG, Thummel KE. Shirasaka Y, et al. Among authors: thummel ke. Pharmacogenomics J. 2016 Aug;16(4):375-87. doi: 10.1038/tpj.2015.58. Epub 2015 Sep 1. Pharmacogenomics J. 2016. PMID: 26323597 Free PMC article.

2

Metabolism of dapsone to its hydroxylamine by CYP2E1 in vitro and in vivo.

Mitra AK, Thummel KE, Kalhorn TF, Kharasch ED, Unadkat JD, Slattery JT. Mitra AK, et al. Among authors: thummel ke. Clin Pharmacol Ther. 1995 Nov;58(5):556-66. doi: 10.1016/0009-9236(95)90176-0. Clin Pharmacol Ther. 1995. PMID: 7586950 Clinical Trial.

3

Use of midazolam as a human cytochrome P450 3A probe: I. In vitro-in vivo correlations in liver transplant patients.

Thummel KE, Shen DD, Podoll TD, Kunze KL, Trager WF, Hartwell PS, Raisys VA, Marsh CL, McVicar JP, Barr DM, et al. Thummel KE, et al. J Pharmacol Exp Ther. 1994 Oct;271(1):549-56. J Pharmacol Exp Ther. 1994. PMID: 7965755

4

Use of midazolam as a human cytochrome P450 3A probe: II. Characterization of inter- and intraindividual hepatic CYP3A variability after liver transplantation.

Thummel KE, Shen DD, Podoll TD, Kunze KL, Trager WF, Bacchi CE, Marsh CL, McVicar JP, Barr DM, Perkins JD, et al. Thummel KE, et al. J Pharmacol Exp Ther. 1994 Oct;271(1):557-66. J Pharmacol Exp Ther. 1994. PMID: 7965756

5

Purification of macaque liver flavin-containing monooxygenase: a form of the enzyme related immunochemically to an isozyme expressed selectively in adult human liver.

Sadeque AJ, Thummel KE, Rettie AE. Sadeque AJ, et al. Among authors: thummel ke. Biochim Biophys Acta. 1993 Mar 5;1162(1-2):127-34. doi: 10.1016/0167-4838(93)90138-h. Biochim Biophys Acta. 1993. PMID: 8448176

6

Human alfentanil metabolism by cytochrome P450 3A3/4. An explanation for the interindividual variability in alfentanil clearance?

Kharasch ED, Thummel KE. Kharasch ED, et al. Among authors: thummel ke. Anesth Analg. 1993 May;76(5):1033-9. doi: 10.1213/00000539-199305000-00022. Anesth Analg. 1993. PMID: 8484504

7

Inhibition of sulfamethoxazole hydroxylamine formation by fluconazole in human liver microsomes and healthy volunteers.

Mitra AK, Thummel KE, Kalhorn TF, Kharasch ED, Unadkat JD, Slattery JT. Mitra AK, et al. Among authors: thummel ke. Clin Pharmacol Ther. 1996 Mar;59(3):332-40. doi: 10.1016/S0009-9236(96)80011-7. Clin Pharmacol Ther. 1996. PMID: 8653996 Clinical Trial.

8

Cytochrome P450 2E1 is the principal catalyst of human oxidative halothane metabolism in vitro.

Spracklin DK, Hankins DC, Fisher JM, Thummel KE, Kharasch ED. Spracklin DK, et al. Among authors: thummel ke. J Pharmacol Exp Ther. 1997 Apr;281(1):400-11. J Pharmacol Exp Ther. 1997. PMID: 9103523

9

Fentanyl metabolism by human hepatic and intestinal cytochrome P450 3A4: implications for interindividual variability in disposition, efficacy, and drug interactions.

Labroo RB, Paine MF, Thummel KE, Kharasch ED. Labroo RB, et al. Among authors: thummel ke. Drug Metab Dispos. 1997 Sep;25(9):1072-80. Drug Metab Dispos. 1997. PMID: 9311623

10

First-pass midazolam metabolism catalyzed by 1alpha,25-dihydroxy vitamin D3-modified Caco-2 cell monolayers.

Fisher JM, Wrighton SA, Watkins PB, Schmiedlin-Ren P, Calamia JC, Shen DD, Kunze KL, Thummel KE. Fisher JM, et al. Among authors: thummel ke. J Pharmacol Exp Ther. 1999 May;289(2):1134-42. J Pharmacol Exp Ther. 1999. PMID: 10215697

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