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Sequence-specific activation of the DNA sensor cGAS by Y-form DNA structures as found in primary HIV-1 cDNA.
Herzner AM, Hagmann CA, Goldeck M, Wolter S, Kübler K, Wittmann S, Gramberg T, Andreeva L, Hopfner KP, Mertens C, Zillinger T, Jin T, Xiao TS, Bartok E, Coch C, Ackermann D, Hornung V, Ludwig J, Barchet W, Hartmann G, Schlee M. Herzner AM, et al. Among authors: hopfner kp. Nat Immunol. 2015 Oct;16(10):1025-33. doi: 10.1038/ni.3267. Epub 2015 Sep 7. Nat Immunol. 2015. PMID: 26343537 Free PMC article.
RIG-I detects infection with live Listeria by sensing secreted bacterial nucleic acids.
Abdullah Z, Schlee M, Roth S, Mraheil MA, Barchet W, Böttcher J, Hain T, Geiger S, Hayakawa Y, Fritz JH, Civril F, Hopfner KP, Kurts C, Ruland J, Hartmann G, Chakraborty T, Knolle PA. Abdullah Z, et al. Among authors: hopfner kp. EMBO J. 2012 Nov 5;31(21):4153-64. doi: 10.1038/emboj.2012.274. Epub 2012 Oct 12. EMBO J. 2012. PMID: 23064150 Free PMC article.
Structural mechanism of cytosolic DNA sensing by cGAS.
Civril F, Deimling T, de Oliveira Mann CC, Ablasser A, Moldt M, Witte G, Hornung V, Hopfner KP. Civril F, et al. Among authors: hopfner kp. Nature. 2013 Jun 20;498(7454):332-7. doi: 10.1038/nature12305. Epub 2013 May 30. Nature. 2013. PMID: 23722159 Free PMC article.
Rad50-CARD9 interactions link cytosolic DNA sensing to IL-1β production.
Roth S, Rottach A, Lotz-Havla AS, Laux V, Muschaweckh A, Gersting SW, Muntau AC, Hopfner KP, Jin L, Vanness K, Petrini JH, Drexler I, Leonhardt H, Ruland J. Roth S, et al. Among authors: hopfner kp. Nat Immunol. 2014 Jun;15(6):538-45. doi: 10.1038/ni.2888. Epub 2014 Apr 28. Nat Immunol. 2014. PMID: 24777530 Free PMC article.
Cytosolic RNA:DNA hybrids activate the cGAS-STING axis.
Mankan AK, Schmidt T, Chauhan D, Goldeck M, Höning K, Gaidt M, Kubarenko AV, Andreeva L, Hopfner KP, Hornung V. Mankan AK, et al. Among authors: hopfner kp. EMBO J. 2014 Dec 17;33(24):2937-46. doi: 10.15252/embj.201488726. Epub 2014 Nov 25. EMBO J. 2014. PMID: 25425575 Free PMC article.
192 results