Bridges HR - Search Results

1

Characterization of clinically identified mutations in NDUFV1, the flavin-binding subunit of respiratory complex I, using a yeast model system.

Varghese F, Atcheson E, Bridges HR, Hirst J. Varghese F, et al. Among authors: bridges hr. Hum Mol Genet. 2015 Nov 15;24(22):6350-60. doi: 10.1093/hmg/ddv344. Epub 2015 Sep 7. Hum Mol Genet. 2015. PMID: 26345448 Free PMC article.

2

The respiratory complexes I from the mitochondria of two Pichia species.

Bridges HR, Grgic L, Harbour ME, Hirst J. Bridges HR, et al. Biochem J. 2009 Jul 29;422(1):151-9. doi: 10.1042/BJ20090492. Biochem J. 2009. PMID: 19459785

3

The subunit composition of mitochondrial NADH:ubiquinone oxidoreductase (complex I) from Pichia pastoris.

Bridges HR, Fearnley IM, Hirst J. Bridges HR, et al. Mol Cell Proteomics. 2010 Oct;9(10):2318-26. doi: 10.1074/mcp.M110.001255. Epub 2010 Jul 7. Mol Cell Proteomics. 2010. PMID: 20610779 Free PMC article.

4

The mitochondrial-encoded subunits of respiratory complex I (NADH:ubiquinone oxidoreductase): identifying residues important in mechanism and disease.

Bridges HR, Birrell JA, Hirst J. Bridges HR, et al. Biochem Soc Trans. 2011 Jun;39(3):799-806. doi: 10.1042/BST0390799. Biochem Soc Trans. 2011. PMID: 21599651

5

Mössbauer spectroscopy on respiratory complex I: the iron-sulfur cluster ensemble in the NADH-reduced enzyme is partially oxidized.

Bridges HR, Bill E, Hirst J. Bridges HR, et al. Biochemistry. 2012 Jan 10;51(1):149-58. doi: 10.1021/bi201644x. Epub 2011 Dec 9. Biochemistry. 2012. PMID: 22122402 Free PMC article.

6

Investigating the function of [2Fe-2S] cluster N1a, the off-pathway cluster in complex I, by manipulating its reduction potential.

Birrell JA, Morina K, Bridges HR, Friedrich T, Hirst J. Birrell JA, et al. Among authors: bridges hr. Biochem J. 2013 Nov 15;456(1):139-46. doi: 10.1042/BJ20130606. Biochem J. 2013. PMID: 23980528 Free PMC article.

7

Effects of metformin and other biguanides on oxidative phosphorylation in mitochondria.

Bridges HR, Jones AJ, Pollak MN, Hirst J. Bridges HR, et al. Biochem J. 2014 Sep 15;462(3):475-87. doi: 10.1042/BJ20140620. Biochem J. 2014. PMID: 25017630 Free PMC article.

8

A Self-Assembled Respiratory Chain that Catalyzes NADH Oxidation by Ubiquinone-10 Cycling between Complex I and the Alternative Oxidase.

Jones AJ, Blaza JN, Bridges HR, May B, Moore AL, Hirst J. Jones AJ, et al. Among authors: bridges hr. Angew Chem Int Ed Engl. 2016 Jan 11;55(2):728-31. doi: 10.1002/anie.201507332. Epub 2015 Nov 23. Angew Chem Int Ed Engl. 2016. PMID: 26592861 Free PMC article.

9

Small-volume potentiometric titrations: EPR investigations of Fe-S cluster N2 in mitochondrial complex I.

Wright JJ, Salvadori E, Bridges HR, Hirst J, Roessler MM. Wright JJ, et al. Among authors: bridges hr. J Inorg Biochem. 2016 Sep;162:201-206. doi: 10.1016/j.jinorgbio.2016.04.025. Epub 2016 Apr 20. J Inorg Biochem. 2016. PMID: 27235270 Free article.

10

Molecular features of biguanides required for targeting of mitochondrial respiratory complex I and activation of AMP-kinase.

Bridges HR, Sirviö VA, Agip AN, Hirst J. Bridges HR, et al. BMC Biol. 2016 Aug 9;14:65. doi: 10.1186/s12915-016-0287-9. BMC Biol. 2016. PMID: 27506389 Free PMC article.

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