Howell LA - Search Results

1

Solid-Phase Synthesis of Duocarmycin Analogues and the Effect of C-Terminal Substitution on Biological Activity.

Stephenson MJ, Howell LA, O'Connell MA, Fox KR, Adcock C, Kingston J, Sheldrake H, Pors K, Collingwood SP, Searcey M. Stephenson MJ, et al. Among authors: howell la. J Org Chem. 2015 Oct 2;80(19):9454-67. doi: 10.1021/acs.joc.5b01373. Epub 2015 Sep 30. J Org Chem. 2015. PMID: 26356089

2

Design and synthesis of threading intercalators to target DNA.

Howell LA, Gulam R, Mueller A, O'Connell MA, Searcey M. Howell LA, et al. Bioorg Med Chem Lett. 2010 Dec 1;20(23):6956-9. doi: 10.1016/j.bmcl.2010.09.128. Epub 2010 Oct 7. Bioorg Med Chem Lett. 2010. PMID: 20980148

3

Synthesis and evaluation of 9-aminoacridines derived from benzyne click chemistry.

Howell LA, Howman A, O'Connell MA, Mueller A, Searcey M. Howell LA, et al. Bioorg Med Chem Lett. 2009 Oct 15;19(20):5880-3. doi: 10.1016/j.bmcl.2009.08.070. Epub 2009 Aug 23. Bioorg Med Chem Lett. 2009. PMID: 19740660

4

Non-covalent duplex to duplex crosslinking of DNA in solution revealed by single molecule force spectroscopy.

Rackham BD, Howell LA, Round AN, Searcey M. Rackham BD, et al. Among authors: howell la. Org Biomol Chem. 2013 Dec 28;11(48):8340-7. doi: 10.1039/c3ob42009d. Epub 2013 Oct 25. Org Biomol Chem. 2013. PMID: 24158749

5

Identification of a new p53/MDM2 inhibitor motif inspired by studies of chlorofusin.

Cominetti MMD, Goffin SA, Raffel E, Turner KD, Ramoutar JC, O'Connell MA, Howell LA, Searcey M. Cominetti MMD, et al. Among authors: howell la. Bioorg Med Chem Lett. 2015 Nov 1;25(21):4878-4880. doi: 10.1016/j.bmcl.2015.06.014. Epub 2015 Jun 14. Bioorg Med Chem Lett. 2015. PMID: 26115576

6

Synthesis of small molecules targeting multiple DNA structures using click chemistry.

Howell LA, Bowater RA, O'Connell MA, Reszka AP, Neidle S, Searcey M. Howell LA, et al. ChemMedChem. 2012 May;7(5):792-804. doi: 10.1002/cmdc.201200060. Epub 2012 Feb 29. ChemMedChem. 2012. PMID: 22378532

7

Identification of Small-Molecule Inhibitors of the Antiapoptotic Protein Myeloid Cell Leukaemia-1 (Mcl-1).

Beekman AM, O'Connell MA, Howell LA. Beekman AM, et al. Among authors: howell la. ChemMedChem. 2016 Apr 19;11(8):840-4. doi: 10.1002/cmdc.201500488. Epub 2015 Nov 30. ChemMedChem. 2016. PMID: 26616140 Free PMC article.

8

Targeting higher-order DNA: beyond the G-quadruplex.

Howell LA, Searcey M. Howell LA, et al. Chembiochem. 2009 Sep 4;10(13):2139-43. doi: 10.1002/cbic.200900243. Chembiochem. 2009. PMID: 19621410 Review. No abstract available.

9

Peptide-Directed Binding for the Discovery of Modulators of α-Helix-Mediated Protein-Protein Interactions: Proof-of-Concept Studies with the Apoptosis Regulator Mcl-1.

Beekman AM, O'Connell MA, Howell LA. Beekman AM, et al. Among authors: howell la. Angew Chem Int Ed Engl. 2017 Aug 21;56(35):10446-10450. doi: 10.1002/anie.201705008. Epub 2017 Jul 25. Angew Chem Int Ed Engl. 2017. PMID: 28670766 Free PMC article.

10

Identification and characterisation of a G-quadruplex forming sequence in the promoter region of nuclear factor (erythroid-derived 2)-like 2 (Nrf2).

Waller ZA, Howell LA, Macdonald CJ, O'Connell MA, Searcey M. Waller ZA, et al. Among authors: howell la. Biochem Biophys Res Commun. 2014 Apr 25;447(1):128-32. doi: 10.1016/j.bbrc.2014.03.117. Epub 2014 Apr 1. Biochem Biophys Res Commun. 2014. PMID: 24699415

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