Ernst M - Search Results

1

Identification of the putative binding pocket of valerenic acid on GABAA receptors using docking studies and site-directed mutagenesis.

Luger D, Poli G, Wieder M, Stadler M, Ke S, Ernst M, Hohaus A, Linder T, Seidel T, Langer T, Khom S, Hering S. Luger D, et al. Among authors: ernst m. Br J Pharmacol. 2015 Nov;172(22):5403-13. doi: 10.1111/bph.13329. Epub 2015 Oct 25. Br J Pharmacol. 2015. PMID: 26375408 Free PMC article.

2

Affinity of various benzodiazepine site ligands in mice with a point mutation in the GABA(A) receptor gamma2 subunit.

Ogris W, Pöltl A, Hauer B, Ernst M, Oberto A, Wulff P, Höger H, Wisden W, Sieghart W. Ogris W, et al. Among authors: ernst m. Biochem Pharmacol. 2004 Oct 15;68(8):1621-9. doi: 10.1016/j.bcp.2004.07.020. Biochem Pharmacol. 2004. PMID: 15451405

3

Comparative models of GABAA receptor extracellular and transmembrane domains: important insights in pharmacology and function.

Ernst M, Bruckner S, Boresch S, Sieghart W. Ernst M, et al. Mol Pharmacol. 2005 Nov;68(5):1291-300. doi: 10.1124/mol.105.015982. Epub 2005 Aug 15. Mol Pharmacol. 2005. PMID: 16103045

4

The GABAA receptor alpha+beta- interface: a novel target for subtype selective drugs.

Ramerstorfer J, Furtmüller R, Sarto-Jackson I, Varagic Z, Sieghart W, Ernst M. Ramerstorfer J, et al. Among authors: ernst m. J Neurosci. 2011 Jan 19;31(3):870-7. doi: 10.1523/JNEUROSCI.5012-10.2011. J Neurosci. 2011. PMID: 21248110 Free PMC article.

5

A novel GABA(A) receptor pharmacology: drugs interacting with the α(+) β(-) interface.

Sieghart W, Ramerstorfer J, Sarto-Jackson I, Varagic Z, Ernst M. Sieghart W, et al. Among authors: ernst m. Br J Pharmacol. 2012 May;166(2):476-85. doi: 10.1111/j.1476-5381.2011.01779.x. Br J Pharmacol. 2012. PMID: 22074382 Free PMC article. Review.

6

Diazepam-bound GABAA receptor models identify new benzodiazepine binding-site ligands.

Richter L, de Graaf C, Sieghart W, Varagic Z, Mörzinger M, de Esch IJ, Ecker GF, Ernst M. Richter L, et al. Among authors: ernst m. Nat Chem Biol. 2012 Mar 25;8(5):455-64. doi: 10.1038/nchembio.917. Nat Chem Biol. 2012. PMID: 22446838 Free PMC article.

7

Identification of novel positive allosteric modulators and null modulators at the GABAA receptor α+β- interface.

Varagic Z, Wimmer L, Schnürch M, Mihovilovic MD, Huang S, Rallapalli S, Cook JM, Mirheydari P, Ecker GF, Sieghart W, Ernst M. Varagic Z, et al. Among authors: ernst m. Br J Pharmacol. 2013 May;169(2):371-83. doi: 10.1111/bph.12151. Br J Pharmacol. 2013. PMID: 23472852 Free PMC article.

8

Subtype selectivity of α+β- site ligands of GABAA receptors: identification of the first highly specific positive modulators at α6β2/3γ2 receptors.

Varagic Z, Ramerstorfer J, Huang S, Rallapalli S, Sarto-Jackson I, Cook J, Sieghart W, Ernst M. Varagic Z, et al. Among authors: ernst m. Br J Pharmacol. 2013 May;169(2):384-99. doi: 10.1111/bph.12153. Br J Pharmacol. 2013. PMID: 23472935 Free PMC article.

9

Unexpected Properties of δ-Containing GABAA Receptors in Response to Ligands Interacting with the α+ β- Site.

Mirheydari P, Ramerstorfer J, Varagic Z, Scholze P, Wimmer L, Mihovilovic MM, Sieghart W, Ernst M. Mirheydari P, et al. Among authors: ernst m. Neurochem Res. 2014 Jun;39(6):1057-1067. doi: 10.1007/s11064-013-1156-3. Epub 2013 Sep 26. Neurochem Res. 2014. PMID: 24072672 Free PMC article.

10

Mutagenesis and computational docking studies support the existence of a histamine binding site at the extracellular β3+β3- interface of homooligomeric β3 GABAA receptors.

Hoerbelt P, Ramerstorfer J, Ernst M, Sieghart W, Thomson JL, Hough LB, Fleck MW. Hoerbelt P, et al. Among authors: ernst m. Neuropharmacology. 2016 Sep;108:252-63. doi: 10.1016/j.neuropharm.2016.04.042. Epub 2016 Apr 30. Neuropharmacology. 2016. PMID: 27140694

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