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The ducky mutation in Cacna2d2 results in altered Purkinje cell morphology and is associated with the expression of a truncated alpha 2 delta-2 protein with abnormal function.
Brodbeck J, Davies A, Courtney JM, Meir A, Balaguero N, Canti C, Moss FJ, Page KM, Pratt WS, Hunt SP, Barclay J, Rees M, Dolphin AC. Brodbeck J, et al. Among authors: pratt ws. J Biol Chem. 2002 Mar 8;277(10):7684-93. doi: 10.1074/jbc.M109404200. Epub 2001 Dec 26. J Biol Chem. 2002. PMID: 11756448 Free article.
Interaction via a key tryptophan in the I-II linker of N-type calcium channels is required for beta1 but not for palmitoylated beta2, implicating an additional binding site in the regulation of channel voltage-dependent properties.
Leroy J, Richards MW, Butcher AJ, Nieto-Rostro M, Pratt WS, Davies A, Dolphin AC. Leroy J, et al. Among authors: pratt ws. J Neurosci. 2005 Jul 27;25(30):6984-96. doi: 10.1523/JNEUROSCI.1137-05.2005. J Neurosci. 2005. PMID: 16049174 Free PMC article.
The stargazin-related protein gamma 7 interacts with the mRNA-binding protein heterogeneous nuclear ribonucleoprotein A2 and regulates the stability of specific mRNAs, including CaV2.2.
Ferron L, Davies A, Page KM, Cox DJ, Leroy J, Waithe D, Butcher AJ, Sellaturay P, Bolsover S, Pratt WS, Moss FJ, Dolphin AC. Ferron L, et al. Among authors: pratt ws. J Neurosci. 2008 Oct 15;28(42):10604-17. doi: 10.1523/JNEUROSCI.2709-08.2008. J Neurosci. 2008. PMID: 18923037 Free PMC article.
34 results