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Antibody-Drug Conjugates (ADCs) Derived from Interchain Cysteine Cross-Linking Demonstrate Improved Homogeneity and Other Pharmacological Properties over Conventional Heterogeneous ADCs.
Behrens CR, Ha EH, Chinn LL, Bowers S, Probst G, Fitch-Bruhns M, Monteon J, Valdiosera A, Bermudez A, Liao-Chan S, Wong T, Melnick J, Theunissen JW, Flory MR, Houser D, Venstrom K, Levashova Z, Sauer P, Migone TS, van der Horst EH, Halcomb RL, Jackson DY. Behrens CR, et al. Mol Pharm. 2015 Nov 2;12(11):3986-98. doi: 10.1021/acs.molpharmaceut.5b00432. Epub 2015 Oct 2. Mol Pharm. 2015. PMID: 26393951 Free PMC article.
Non-clinical immunological comparison of a Next-Generation 24-valent pneumococcal conjugate vaccine (VAX-24) using site-specific carrier protein conjugation to the current standard of care (PCV13 and PPV23).
Fairman J, Agarwal P, Barbanel S, Behrens C, Berges A, Burky J, Davey P, Fernsten P, Grainger C, Guo S, Iki S, Iverson M, Kane M, Kapoor N, Marcq O, Migone TS, Sauer P, Wassil J. Fairman J, et al. Vaccine. 2021 May 27;39(23):3197-3206. doi: 10.1016/j.vaccine.2021.03.070. Epub 2021 May 6. Vaccine. 2021. PMID: 33965258 Free article.
Potent Activity of an Anti-ICAM1 Antibody-Drug Conjugate against Multiple Myeloma.
Sherbenou DW, Su Y, Behrens CR, Aftab BT, Perez de Acha O, Murnane M, Bearrows SC, Hann BC, Wolf JL, Martin TG, Liu B. Sherbenou DW, et al. Among authors: behrens cr. Clin Cancer Res. 2020 Nov 15;26(22):6028-6038. doi: 10.1158/1078-0432.CCR-20-0400. Epub 2020 Sep 11. Clin Cancer Res. 2020. PMID: 32917735 Free PMC article.
The development of potential antibody-based therapies for myeloma.
Sherbenou DW, Behrens CR, Su Y, Wolf JL, Martin TG 3rd, Liu B. Sherbenou DW, et al. Among authors: behrens cr. Blood Rev. 2015 Mar;29(2):81-91. doi: 10.1016/j.blre.2014.09.011. Epub 2014 Sep 28. Blood Rev. 2015. PMID: 25294123 Free PMC article. Review.
Antibody-drug conjugate targeting CD46 eliminates multiple myeloma cells.
Sherbenou DW, Aftab BT, Su Y, Behrens CR, Wiita A, Logan AC, Acosta-Alvear D, Hann BC, Walter P, Shuman MA, Wu X, Atkinson JP, Wolf JL, Martin TG, Liu B. Sherbenou DW, et al. Among authors: behrens cr. J Clin Invest. 2016 Dec 1;126(12):4640-4653. doi: 10.1172/JCI85856. Epub 2016 Nov 14. J Clin Invest. 2016. PMID: 27841764 Free PMC article.
Addition of Lauryldimethylamine N-Oxide (LDAO) to a Copper-Free Click Chemistry Reaction Improves the Conjugation Efficiency of a Cell-Free Generated CRM197 Variant to Clinically Important Streptococcus pneumoniae Serotypes.
Bautista L, Pill-Pepe L, Kapoor N, Snyder S, Chu E, Agarwal P, Sardar M, Arulkumar S, Berges A, Iverson M, Behrens C, Marcq O, Fairman J. Bautista L, et al. ACS Omega. 2022 Sep 20;7(39):34921-34928. doi: 10.1021/acsomega.2c03481. eCollection 2022 Oct 4. ACS Omega. 2022. PMID: 36211053 Free PMC article.
ALPPL2 Is a Highly Specific and Targetable Tumor Cell Surface Antigen.
Su Y, Zhang X, Bidlingmaier S, Behrens CR, Lee NK, Liu B. Su Y, et al. Among authors: behrens cr. Cancer Res. 2020 Oct 15;80(20):4552-4564. doi: 10.1158/0008-5472.CAN-20-1418. Epub 2020 Aug 31. Cancer Res. 2020. PMID: 32868383 Free PMC article.
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