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QIAD assay for quantitating a compound's efficacy in elimination of toxic Aβ oligomers.
Brener O, Dunkelmann T, Gremer L, van Groen T, Mirecka EA, Kadish I, Willuweit A, Kutzsche J, Jürgens D, Rudolph S, Tusche M, Bongen P, Pietruszka J, Oesterhelt F, Langen KJ, Demuth HU, Janssen A, Hoyer W, Funke SA, Nagel-Steger L, Willbold D. Brener O, et al. Sci Rep. 2015 Sep 23;5:13222. doi: 10.1038/srep13222. Sci Rep. 2015. PMID: 26394756 Free PMC article.
Oral treatment with the d-enantiomeric peptide D3 improves the pathology and behavior of Alzheimer's Disease transgenic mice.
Aileen Funke S, van Groen T, Kadish I, Bartnik D, Nagel-Steger L, Brener O, Sehl T, Batra-Safferling R, Moriscot C, Schoehn G, Horn AH, Müller-Schiffmann A, Korth C, Sticht H, Willbold D. Aileen Funke S, et al. ACS Chem Neurosci. 2010 Sep 15;1(9):639-48. doi: 10.1021/cn100057j. Epub 2010 Aug 2. ACS Chem Neurosci. 2010. PMID: 22778851 Free PMC article.
The off-rate of monomers dissociating from amyloid-β protofibrils.
Grüning CS, Klinker S, Wolff M, Schneider M, Toksöz K, Klein AN, Nagel-Steger L, Willbold D, Hoyer W. Grüning CS, et al. J Biol Chem. 2013 Dec 27;288(52):37104-11. doi: 10.1074/jbc.M113.513432. Epub 2013 Nov 18. J Biol Chem. 2013. PMID: 24247242 Free PMC article.
The centrosomal adaptor TACC3 and the microtubule polymerase chTOG interact via defined C-terminal subdomains in an Aurora-A kinase-independent manner.
Thakur HC, Singh M, Nagel-Steger L, Kremer J, Prumbaum D, Fansa EK, Ezzahoini H, Nouri K, Gremer L, Abts A, Schmitt L, Raunser S, Ahmadian MR, Piekorz RP. Thakur HC, et al. J Biol Chem. 2014 Jan 3;289(1):74-88. doi: 10.1074/jbc.M113.532333. Epub 2013 Nov 22. J Biol Chem. 2014. PMID: 24273164 Free PMC article.
60 results