Ritschel T - Search Results

1

Statin Lactonization by Uridine 5'-Diphospho-glucuronosyltransferases (UGTs).

Schirris TJ, Ritschel T, Bilos A, Smeitink JA, Russel FG. Schirris TJ, et al. Among authors: ritschel t. Mol Pharm. 2015 Nov 2;12(11):4048-55. doi: 10.1021/acs.molpharmaceut.5b00474. Epub 2015 Oct 6. Mol Pharm. 2015. PMID: 26412035

2

Statin-Induced Myopathy Is Associated with Mitochondrial Complex III Inhibition.

Schirris TJ, Renkema GH, Ritschel T, Voermans NC, Bilos A, van Engelen BG, Brandt U, Koopman WJ, Beyrath JD, Rodenburg RJ, Willems PH, Smeitink JA, Russel FG. Schirris TJ, et al. Among authors: ritschel t. Cell Metab. 2015 Sep 1;22(3):399-407. doi: 10.1016/j.cmet.2015.08.002. Cell Metab. 2015. PMID: 26331605 Free article.

3

Mitochondrial ADP/ATP exchange inhibition: a novel off-target mechanism underlying ibipinabant-induced myotoxicity.

Schirris TJ, Ritschel T, Herma Renkema G, Willems PH, Smeitink JA, Russel FG. Schirris TJ, et al. Among authors: ritschel t. Sci Rep. 2015 Sep 29;5:14533. doi: 10.1038/srep14533. Sci Rep. 2015. PMID: 26416158 Free PMC article.

4

In silico identification and in vitro validation of potential cholestatic compounds through 3D ligand-based pharmacophore modeling of BSEP inhibitors.

Ritschel T, Hermans SM, Schreurs M, van den Heuvel JJ, Koenderink JB, Greupink R, Russel FG. Ritschel T, et al. Chem Res Toxicol. 2014 May 19;27(5):873-81. doi: 10.1021/tx5000393. Epub 2014 Apr 23. Chem Res Toxicol. 2014. PMID: 24713091

5

KRIPO - a structure-based pharmacophores approach explains polypharmacological effects.

Ritschel T, Schirris TJ, Russel FG. Ritschel T, et al. J Cheminform. 2014 Mar 11;6(Suppl 1):O26. doi: 10.1186/1758-2946-6-S1-O26. eCollection 2014 Mar. J Cheminform. 2014. PMID: 24765125 Free PMC article. No abstract available.

6

Involvement of a Hydrophobic Pocket and Helix 11 in Determining the Modes of Action of Prenylated Flavonoids and Isoflavonoids in the Human Estrogen Receptor.

van de Schans MG, Ritschel T, Bovee TF, Sanders MG, de Waard P, Gruppen H, Vincken JP. van de Schans MG, et al. Among authors: ritschel t. Chembiochem. 2015 Dec;16(18):2668-77. doi: 10.1002/cbic.201500343. Epub 2015 Nov 4. Chembiochem. 2015. PMID: 26449282

7

Snooker structure-based pharmacophore model explains differences in agonist and blocker binding to bitter receptor hTAS2R39.

Roland WS, Sanders MP, van Buren L, Gouka RJ, Gruppen H, Vincken JP, Ritschel T. Roland WS, et al. Among authors: ritschel t. PLoS One. 2015 Mar 2;10(3):e0118200. doi: 10.1371/journal.pone.0118200. eCollection 2015. PLoS One. 2015. PMID: 25729848 Free PMC article.

8

Molecular interaction fingerprint approaches for GPCR drug discovery.

Vass M, Kooistra AJ, Ritschel T, Leurs R, de Esch IJ, de Graaf C. Vass M, et al. Among authors: ritschel t. Curr Opin Pharmacol. 2016 Oct;30:59-68. doi: 10.1016/j.coph.2016.07.007. Epub 2016 Jul 29. Curr Opin Pharmacol. 2016. PMID: 27479316 Review.

9

Drug Discovery and Repurposing Inhibits a Major Gut Pathogen-Derived Oncogenic Toxin.

Metz P, Tjan MJH, Wu S, Pervaiz M, Hermans S, Shettigar A, Sears CL, Ritschel T, Dutilh BE, Boleij A. Metz P, et al. Among authors: ritschel t. Front Cell Infect Microbiol. 2019 Oct 25;9:364. doi: 10.3389/fcimb.2019.00364. eCollection 2019. Front Cell Infect Microbiol. 2019. PMID: 31709196 Free PMC article.

10

Pharmacophore fingerprint-based approach to binding site subpocket similarity and its application to bioisostere replacement.

Wood DJ, de Vlieg J, Wagener M, Ritschel T. Wood DJ, et al. Among authors: ritschel t. J Chem Inf Model. 2012 Aug 27;52(8):2031-43. doi: 10.1021/ci3000776. Epub 2012 Aug 16. J Chem Inf Model. 2012. PMID: 22830492

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