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Sesquiterpene dimmer (DSF-27) inhibits the release of neuroinflammatory mediators from microglia by targeting spleen tyrosine kinase (Syk) and Janus kinase 2 (Jak2): Two major non-receptor tyrosine signaling proteins involved in inflammatory events.
Zeng KW, Wang S, Dong X, Jiang Y, Jin HW, Tu PF. Zeng KW, et al. Among authors: dong x. Toxicol Appl Pharmacol. 2014 Mar 15;275(3):244-56. doi: 10.1016/j.taap.2014.01.014. Epub 2014 Jan 28. Toxicol Appl Pharmacol. 2014. PMID: 24486434
Deoxysappanone B, a homoisoflavone from the Chinese medicinal plant Caesalpinia sappan L., protects neurons from microglia-mediated inflammatory injuries via inhibition of IκB kinase (IKK)-NF-κB and p38/ERK MAPK pathways.
Zeng KW, Yu Q, Song FJ, Liao LX, Zhao MB, Dong X, Jiang Y, Tu PF. Zeng KW, et al. Among authors: dong x. Eur J Pharmacol. 2015 Feb 5;748:18-29. doi: 10.1016/j.ejphar.2014.12.013. Epub 2014 Dec 18. Eur J Pharmacol. 2015. PMID: 25530267
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