Akgün E - Search Results

1

Inhibition of Inflammatory and Neuropathic Pain by Targeting a Mu Opioid Receptor/Chemokine Receptor5 Heteromer (MOR-CCR5).

Akgün E, Javed MI, Lunzer MM, Powers MD, Sham YY, Watanabe Y, Portoghese PS. Akgün E, et al. J Med Chem. 2015 Nov 12;58(21):8647-57. doi: 10.1021/acs.jmedchem.5b01245. Epub 2015 Oct 20. J Med Chem. 2015. PMID: 26451468 Free PMC article.

2

Induced association of mu opioid (MOP) and type 2 cholecystokinin (CCK2) receptors by novel bivalent ligands.

Zheng Y, Akgün E, Harikumar KG, Hopson J, Powers MD, Lunzer MM, Miller LJ, Portoghese PS. Zheng Y, et al. Among authors: akgun e. J Med Chem. 2009 Jan 22;52(2):247-58. doi: 10.1021/jm800174p. J Med Chem. 2009. PMID: 19113864 Free PMC article.

3

Synthesis and in vitro characterization of radioiodinatable benzodiazepines selective for type 1 and type 2 cholecystokinin receptors.

Akgün E, Körner M, Gao F, Harikumar KG, Waser B, Reubi JC, Portoghese PS, Miller LJ. Akgün E, et al. J Med Chem. 2009 Apr 9;52(7):2138-47. doi: 10.1021/jm801439x. J Med Chem. 2009. PMID: 19271701 Free PMC article.

4

Modulation of cell surface expression of nonactivated cholecystokinin receptors using bivalent ligand-induced internalization.

Harikumar KG, Akgün E, Portoghese PS, Miller LJ. Harikumar KG, et al. Among authors: akgun e. J Med Chem. 2010 Apr 8;53(7):2836-42. doi: 10.1021/jm100135g. J Med Chem. 2010. PMID: 20235611 Free PMC article.

5

Molecular basis for binding and subtype selectivity of 1,4-benzodiazepine antagonist ligands of the cholecystokinin receptor.

Cawston EE, Lam PC, Harikumar KG, Dong M, Ball AM, Augustine ML, Akgün E, Portoghese PS, Orry A, Abagyan R, Sexton PM, Miller LJ. Cawston EE, et al. Among authors: akgun e. J Biol Chem. 2012 May 25;287(22):18618-35. doi: 10.1074/jbc.M111.335646. Epub 2012 Mar 30. J Biol Chem. 2012. PMID: 22467877 Free PMC article.

6

Bivalent ligands that target μ opioid (MOP) and cannabinoid1 (CB1) receptors are potent analgesics devoid of tolerance.

Le Naour M, Akgün E, Yekkirala A, Lunzer MM, Powers MD, Kalyuzhny AE, Portoghese PS. Le Naour M, et al. Among authors: akgun e. J Med Chem. 2013 Jul 11;56(13):5505-13. doi: 10.1021/jm4005219. Epub 2013 Jun 20. J Med Chem. 2013. PMID: 23734559 Free PMC article.

7

Ligands that interact with putative MOR-mGluR5 heteromer in mice with inflammatory pain produce potent antinociception.

Akgün E, Javed MI, Lunzer MM, Smeester BA, Beitz AJ, Portoghese PS. Akgün E, et al. Proc Natl Acad Sci U S A. 2013 Jul 9;110(28):11595-9. doi: 10.1073/pnas.1305461110. Epub 2013 Jun 24. Proc Natl Acad Sci U S A. 2013. PMID: 23798416 Free PMC article.

8

Targeting putative mu opioid/metabotropic glutamate receptor-5 heteromers produces potent antinociception in a chronic murine bone cancer model.

Smeester BA, Lunzer MM, Akgün E, Beitz AJ, Portoghese PS. Smeester BA, et al. Among authors: akgun e. Eur J Pharmacol. 2014 Nov 15;743:48-52. doi: 10.1016/j.ejphar.2014.09.008. Epub 2014 Sep 17. Eur J Pharmacol. 2014. PMID: 25239072 Free PMC article.

9

MDAN-21: A Bivalent Opioid Ligand Containing mu-Agonist and Delta-Antagonist Pharmacophores and Its Effects in Rhesus Monkeys.

Aceto MD, Harris LS, Negus SS, Banks ML, Hughes LD, Akgün E, Portoghese PS. Aceto MD, et al. Among authors: akgun e. Int J Med Chem. 2012;2012:327257. doi: 10.1155/2012/327257. Epub 2012 Apr 29. Int J Med Chem. 2012. PMID: 25954526 Free PMC article.

10

Heteromer Induction: An Approach to Unique Pharmacology?

Portoghese PS, Akgün E, Lunzer MM. Portoghese PS, et al. Among authors: akgun e. ACS Chem Neurosci. 2017 Mar 15;8(3):426-428. doi: 10.1021/acschemneuro.7b00002. Epub 2017 Jan 31. ACS Chem Neurosci. 2017. PMID: 28139906

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