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PTEN catalysis of phospholipid dephosphorylation reaction follows a two-step mechanism in which the conserved aspartate-92 does not function as the general acid--mechanistic analysis of a familial Cowden disease-associated PTEN mutation.
Xiao Y, Yeong Chit Chia J, Gajewski JE, Sio Seng Lio D, Mulhern TD, Zhu HJ, Nandurkar H, Cheng HC. Xiao Y, et al. Among authors: zhu hj. Cell Signal. 2007 Jul;19(7):1434-45. doi: 10.1016/j.cellsig.2007.01.021. Epub 2007 Jan 25. Cell Signal. 2007. PMID: 17324556
Defining the substrate specificity determinants recognized by the active site of C-terminal Src kinase-homologous kinase (CHK) and identification of β-synuclein as a potential CHK physiological substrate.
Ia KK, Jeschke GR, Deng Y, Kamaruddin MA, Williamson NA, Scanlon DB, Culvenor JG, Hossain MI, Purcell AW, Liu S, Zhu HJ, Catimel B, Turk BE, Cheng HC. Ia KK, et al. Among authors: zhu hj. Biochemistry. 2011 Aug 9;50(31):6667-77. doi: 10.1021/bi2001938. Epub 2011 Jul 18. Biochemistry. 2011. PMID: 21699177 Free PMC article.
Regulation and function of protein kinases and phosphatases.
Cheng HC, Qi RZ, Paudel H, Zhu HJ. Cheng HC, et al. Among authors: zhu hj. Enzyme Res. 2011;2011:794089. doi: 10.4061/2011/794089. Epub 2011 Dec 13. Enzyme Res. 2011. PMID: 22195276 Free PMC article. No abstract available.
Csk-homologous kinase (Chk) is an efficient inhibitor of Src-family kinases but a poor catalyst of phosphorylation of their C-terminal regulatory tyrosine.
Advani G, Lim YC, Catimel B, Lio DSS, Ng NLY, Chüeh AC, Tran M, Anasir MI, Verkade H, Zhu HJ, Turk BE, Smithgall TE, Ang CS, Griffin M, Cheng HC. Advani G, et al. Among authors: zhu hj. Cell Commun Signal. 2017 Aug 7;15(1):29. doi: 10.1186/s12964-017-0186-x. Cell Commun Signal. 2017. PMID: 28784162 Free PMC article.
CSK-homologous kinase (CHK/MATK) is a potential colorectal cancer tumour suppressor gene epigenetically silenced by promoter methylation.
Chüeh AC, Advani G, Foroutan M, Smith J, Ng N, Nandurkar H, Lio DS, Zhu HJ, Chong YP, Verkade H, Fujita DJ, Bjorge J, Basheer F, Lim JP, Luk I, Dhillon A, Sakthianandeswaren A, Mouradov D, Sieber O, Hollande F, Mariadason JM, Cheng HC. Chüeh AC, et al. Among authors: zhu hj. Oncogene. 2021 Apr;40(17):3015-3029. doi: 10.1038/s41388-021-01755-z. Epub 2021 Mar 25. Oncogene. 2021. PMID: 33767439
N-Terminomic Changes in Neurons During Excitotoxicity Reveal Proteolytic Events Associated With Synaptic Dysfunctions and Potential Targets for Neuroprotection.
Ameen SS, Griem-Krey N, Dufour A, Hossain MI, Hoque A, Sturgeon S, Nandurkar H, Draxler DF, Medcalf RL, Kamaruddin MA, Lucet IS, Leeming MG, Liu D, Dhillon A, Lim JP, Basheer F, Zhu HJ, Bokhari L, Roulston CL, Paradkar PN, Kleifeld O, Clarkson AN, Wellendorph P, Ciccotosto GD, Williamson NA, Ang CS, Cheng HC. Ameen SS, et al. Among authors: zhu hj. Mol Cell Proteomics. 2023 May;22(5):100543. doi: 10.1016/j.mcpro.2023.100543. Epub 2023 Apr 6. Mol Cell Proteomics. 2023. PMID: 37030595 Free PMC article.
649 results