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Small molecule adiponectin receptor agonist GTDF protects against skeletal muscle atrophy.
Singh AK, Shree S, Chattopadhyay S, Kumar S, Gurjar A, Kushwaha S, Kumar H, Trivedi AK, Chattopadhyay N, Maurya R, Ramachandran R, Sanyal S. Singh AK, et al. Among authors: kumar h, kumar s. Mol Cell Endocrinol. 2017 Jan 5;439:273-285. doi: 10.1016/j.mce.2016.09.013. Epub 2016 Sep 16. Mol Cell Endocrinol. 2017. PMID: 27645900
Orally active osteoanabolic agent GTDF binds to adiponectin receptors, with a preference for AdipoR1, induces adiponectin-associated signaling, and improves metabolic health in a rodent model of diabetes.
Singh AK, Joharapurkar AA, Khan MP, Mishra JS, Singh N, Yadav M, Hossain Z, Khan K, Kumar S, Dhanesha NA, Mishra DP, Maurya R, Sharma S, Jain MR, Trivedi AK, Godbole MM, Gayen JR, Chattopadhyay N, Sanyal S. Singh AK, et al. Among authors: kumar s. Diabetes. 2014 Oct;63(10):3530-44. doi: 10.2337/db13-1619. Epub 2014 May 21. Diabetes. 2014. PMID: 24848063
A butanolic fraction from the standardized stem extract of Cassia occidentalis L delivered by a self-emulsifying drug delivery system protects rats from glucocorticoid-induced osteopenia and muscle atrophy.
Pal S, Mittapelly N, Husain A, Kushwaha S, Chattopadhyay S, Kumar P, Ramakrishna E, Kumar S, Maurya R, Sanyal S, Gayen JR, Mishra PR, Chattopadhyay N. Pal S, et al. Among authors: kumar s, kumar p. Sci Rep. 2020 Jan 13;10(1):195. doi: 10.1038/s41598-019-56853-6. Sci Rep. 2020. PMID: 31932603 Free PMC article.
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