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Synthesis and biological evaluation of 1-substituted-3(5)-(6-methylpyridin-2-yl)-4-(quinoxalin-6-yl)pyrazoles as transforming growth factor-β type 1 receptor kinase inhibitors.
Jin CH, Sreenu D, Krishnaiah M, Subrahmanyam VB, Rao KS, Nagendra Mohan AV, Park CY, Son JY, Son DH, Park HJ, Sheen YY, Kim DK. Jin CH, et al. Among authors: sheen yy. Eur J Med Chem. 2011 Sep;46(9):3917-25. doi: 10.1016/j.ejmech.2011.05.063. Epub 2011 Jun 22. Eur J Med Chem. 2011. PMID: 21696866
Synthesis and biological evaluation of 1-substituted-3-(6-methylpyridin-2-yl)-4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)pyrazoles as transforming growth factor-β type 1 receptor kinase inhibitors.
Jin CH, Krishnaiah M, Sreenu D, Subrahmanyam VB, Rao KS, Mohan AV, Park CY, Son JY, Sheen YY, Kim DK. Jin CH, et al. Among authors: sheen yy. Bioorg Med Chem Lett. 2011 Oct 15;21(20):6049-53. doi: 10.1016/j.bmcl.2011.08.064. Epub 2011 Aug 22. Bioorg Med Chem Lett. 2011. PMID: 21911290
Synthesis and biological evaluation of 2-benzylamino-4(5)-(6-methylpyridin-2-yl)-5(4)-([1,2,4]triazolo[1,5-a]-pyridin-6-yl)thiazoles as transforming growth factor-β type 1 receptor kinase inhibitors.
Krishnaiah M, Jin CH, Sreenu D, Subrahmanyam VB, Rao KS, Son DH, Park HJ, Kim SW, Sheen YY, Kim DK. Krishnaiah M, et al. Among authors: sheen yy. Eur J Med Chem. 2012 Nov;57:74-84. doi: 10.1016/j.ejmech.2012.09.011. Epub 2012 Sep 20. Eur J Med Chem. 2012. PMID: 23047226
Discovery of N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)-2-fluoroaniline (EW-7197): a highly potent, selective, and orally bioavailable inhibitor of TGF-β type I receptor kinase as cancer immunotherapeutic/antifibrotic agent.
Jin CH, Krishnaiah M, Sreenu D, Subrahmanyam VB, Rao KS, Lee HJ, Park SJ, Park HJ, Lee K, Sheen YY, Kim DK. Jin CH, et al. Among authors: sheen yy. J Med Chem. 2014 May 22;57(10):4213-38. doi: 10.1021/jm500115w. Epub 2014 May 13. J Med Chem. 2014. PMID: 24786585
81 results