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Design of 4-Oxo-1-aryl-1,4-dihydroquinoline-3-carboxamides as Selective Negative Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 2.
Felts AS, Rodriguez AL, Smith KA, Engers JL, Morrison RD, Byers FW, Blobaum AL, Locuson CW, Chang S, Venable DF, Niswender CM, Daniels JS, Conn PJ, Lindsley CW, Emmitte KA. Felts AS, et al. Among authors: smith ka. J Med Chem. 2015 Nov 25;58(22):9027-40. doi: 10.1021/acs.jmedchem.5b01371. Epub 2015 Nov 11. J Med Chem. 2015. PMID: 26524606 Free PMC article.
Discovery of (R)-(2-fluoro-4-((-4-methoxyphenyl)ethynyl)phenyl) (3-hydroxypiperidin-1-yl)methanone (ML337), an mGlu3 selective and CNS penetrant negative allosteric modulator (NAM).
Wenthur CJ, Morrison R, Felts AS, Smith KA, Engers JL, Byers FW, Daniels JS, Emmitte KA, Conn PJ, Lindsley CW. Wenthur CJ, et al. Among authors: smith ka. J Med Chem. 2013 Jun 27;56(12):5208-12. doi: 10.1021/jm400439t. Epub 2013 Jun 13. J Med Chem. 2013. PMID: 23718281 Free PMC article.
Brain-wide cell-type-specific transcriptomic signatures of healthy ageing in mice.
Jin K, Yao Z, van Velthoven CTJ, Kaplan ES, Glattfelder K, Barlow ST, Boyer G, Carey D, Casper T, Chakka AB, Chakrabarty R, Clark M, Departee M, Desierto M, Gary A, Gloe J, Goldy J, Guilford N, Guzman J, Hirschstein D, Lee C, Liang E, Pham T, Reding M, Ronellenfitch K, Ruiz A, Sevigny J, Shapovalova N, Shulga L, Sulc J, Torkelson A, Tung H, Levi B, Sunkin SM, Dee N, Esposito L, Smith KA, Tasic B, Zeng H. Jin K, et al. Among authors: smith ka. Nature. 2025 Jan 1. doi: 10.1038/s41586-024-08350-8. Online ahead of print. Nature. 2025. PMID: 39743592
Triangulating evidence from the GALENOS living systematic review on trace amine-associated receptor 1 (TAAR1) agonists in psychosis.
Smith KA, Boyce N, Chevance A, Chiocchia V, Correll CU, Donoghue K, Ghodke N, Kambeu T, Malhi GS, Macleod M, Milligan L, Morgan J, Potts J, Robinson ESJ, Siafis S, Sommer IEC, Voelkl B, Salanti G, Cipriani A, Higgins JPT. Smith KA, et al. Br J Psychiatry. 2024 Dec 23:1-9. doi: 10.1192/bjp.2024.237. Online ahead of print. Br J Psychiatry. 2024. PMID: 39710623
Improving Blood Pressure Control and Tobacco Use Cessation Intervention In Primary Care: Protocol for the Alabama Cardiovascular Cooperative Heart Health Improvement Project.
Foti K, Hubbard D, Smith KA, Hearld L, Richman J, Horton T, Parker S, Roughton D, Craft M, Clarkson SA, Jackson EA, Cherrington AL. Foti K, et al. Among authors: smith ka. JMIR Res Protoc. 2024 Dec 20;13:e63685. doi: 10.2196/63685. JMIR Res Protoc. 2024. PMID: 39706585 Free PMC article.
1,191 results