Núñez LE - Search Results

1

Pleiotropic Anti-Angiogenic and Anti-Oncogenic Activities of the Novel Mithralog Demycarosyl-3D-ß-D-Digitoxosyl-Mithramycin SK (EC-8042).

Fernández-Guizán A, López-Soto A, Acebes-Huerta A, Huergo-Zapico L, Villa-Álvarez M, Núñez LE, Morís F, Gonzalez S. Fernández-Guizán A, et al. Among authors: nunez le. PLoS One. 2015 Nov 4;10(11):e0140786. doi: 10.1371/journal.pone.0140786. eCollection 2015. PLoS One. 2015. PMID: 26536461 Free PMC article.

2

The activity of a novel mithramycin analog is related to its binding to DNA, cellular accumulation, and inhibition of Sp1-driven gene transcription.

Fernández-Guizán A, Mansilla S, Barceló F, Vizcaíno C, Núñez LE, Morís F, González S, Portugal J. Fernández-Guizán A, et al. Among authors: nunez le. Chem Biol Interact. 2014 Aug 5;219:123-32. doi: 10.1016/j.cbi.2014.05.019. Epub 2014 Jun 4. Chem Biol Interact. 2014. PMID: 24907531 Free article.

3

Genome-wide modulation of gene transcription in ovarian carcinoma cells by a new mithramycin analogue.

Vizcaíno C, Núñez LE, Morís F, Portugal J. Vizcaíno C, et al. Among authors: nunez le. PLoS One. 2014 Aug 11;9(8):e104687. doi: 10.1371/journal.pone.0104687. eCollection 2014. PLoS One. 2014. PMID: 25110883 Free PMC article.

4

Cytotoxic effects of mithramycin DIG-MSK can depend on the rise of autophagy.

Vizcaíno C, Rodríguez-Sánchez MA, Núñez LE, Morís F, Portugal J. Vizcaíno C, et al. Among authors: nunez le. Toxicol In Vitro. 2015 Oct;29(7):1537-44. doi: 10.1016/j.tiv.2015.06.008. Epub 2015 Jun 13. Toxicol In Vitro. 2015. PMID: 26079942

5

Antitumoral activity of the mithralog EC-8042 in triple negative breast cancer linked to cell cycle arrest in G2.

Pandiella A, Morís F, Ocaña A, Núñez LE, Montero JC. Pandiella A, et al. Among authors: nunez le. Oncotarget. 2015 Oct 20;6(32):32856-67. doi: 10.18632/oncotarget.5942. Oncotarget. 2015. PMID: 26439989 Free PMC article.

6

Inhibition of SP1 by the mithramycin analog EC-8042 efficiently targets tumor initiating cells in sarcoma.

Tornin J, Martinez-Cruzado L, Santos L, Rodriguez A, Núñez LE, Oro P, Hermosilla MA, Allonca E, Fernández-García MT, Astudillo A, Suarez C, Morís F, Rodriguez R. Tornin J, et al. Among authors: nunez le. Oncotarget. 2016 May 24;7(21):30935-50. doi: 10.18632/oncotarget.8817. Oncotarget. 2016. PMID: 27105533 Free PMC article.

7

The Mithralog EC-7072 Induces Chronic Lymphocytic Leukemia Cell Death by Targeting Tonic B-Cell Receptor Signaling.

Lorenzo-Herrero S, Sordo-Bahamonde C, Bretones G, Payer ÁR, González-Rodríguez AP, González-García E, Pérez-Escuredo J, Villa-Álvarez M, Núñez LE, Morís F, Gonzalez S, López-Soto A. Lorenzo-Herrero S, et al. Among authors: nunez le. Front Immunol. 2019 Oct 18;10:2455. doi: 10.3389/fimmu.2019.02455. eCollection 2019. Front Immunol. 2019. PMID: 31681329 Free PMC article.

8

A novel mithramycin analogue with high antitumor activity and less toxicity generated by combinatorial biosynthesis.

Núñez LE, Nybo SE, González-Sabín J, Pérez M, Menéndez N, Braña AF, Shaaban KA, He M, Morís F, Salas JA, Rohr J, Méndez C. Núñez LE, et al. J Med Chem. 2012 Jun 28;55(12):5813-25. doi: 10.1021/jm300234t. Epub 2012 Jun 7. J Med Chem. 2012. PMID: 22578073 Free PMC article.

9

Modulation of the activity of Sp transcription factors by mithramycin analogues as a new strategy for treatment of metastatic prostate cancer.

Malek A, Núñez LE, Magistri M, Brambilla L, Jovic S, Carbone GM, Morís F, Catapano CV. Malek A, et al. Among authors: nunez le. PLoS One. 2012;7(4):e35130. doi: 10.1371/journal.pone.0035130. Epub 2012 Apr 19. PLoS One. 2012. PMID: 22545098 Free PMC article.

10

Novel mithramycins abrogate the involvement of protein factors in the transcription of cell cycle control genes.

Vizcaíno C, Mansilla S, Núñez LE, Méndez C, Salas JA, Morís F, Portugal J. Vizcaíno C, et al. Among authors: nunez le. Biochem Pharmacol. 2012 Nov 1;84(9):1133-42. doi: 10.1016/j.bcp.2012.08.003. Epub 2012 Aug 14. Biochem Pharmacol. 2012. PMID: 22981341

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