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SIRT5 inhibits peroxisomal ACOX1 to prevent oxidative damage and is downregulated in liver cancer.
Chen XF, Tian MX, Sun RQ, Zhang ML, Zhou LS, Jin L, Chen LL, Zhou WJ, Duan KL, Chen YJ, Gao C, Cheng ZL, Wang F, Zhang JY, Sun YP, Yu HX, Zhao YZ, Yang Y, Liu WR, Shi YH, Xiong Y, Guan KL, Ye D. Chen XF, et al. Among authors: chen ll, chen yj. EMBO Rep. 2018 May;19(5):e45124. doi: 10.15252/embr.201745124. Epub 2018 Feb 28. EMBO Rep. 2018. PMID: 29491006 Free PMC article.
SNIP1 Recruits TET2 to Regulate c-MYC Target Genes and Cellular DNA Damage Response.
Chen LL, Lin HP, Zhou WJ, He CX, Zhang ZY, Cheng ZL, Song JB, Liu P, Chen XY, Xia YK, Chen XF, Sun RQ, Zhang JY, Sun YP, Song L, Liu BJ, Du RK, Ding C, Lan F, Huang SL, Zhou F, Liu S, Xiong Y, Ye D, Guan KL. Chen LL, et al. Among authors: chen xy, chen xf. Cell Rep. 2018 Nov 6;25(6):1485-1500.e4. doi: 10.1016/j.celrep.2018.10.028. Cell Rep. 2018. PMID: 30404004 Free PMC article.
Tumour metabolites hinder DNA repair.
Chen LL, Xiong Y. Chen LL, et al. Nature. 2020 Jun;582(7813):492-494. doi: 10.1038/d41586-020-01569-1. Nature. 2020. PMID: 32572248 Free PMC article. No abstract available.
Itaconate inhibits TET DNA dioxygenases to dampen inflammatory responses.
Chen LL, Morcelle C, Cheng ZL, Chen X, Xu Y, Gao Y, Song J, Li Z, Smith MD, Shi M, Zhu Y, Zhou N, Cheng M, He C, Liu KY, Lu G, Zhang L, Zhang C, Zhang J, Sun Y, Qi T, Lyu Y, Ren ZZ, Tan XM, Yin J, Lan F, Liu Y, Yang H, Qian M, Duan C, Chang X, Zhou Y, Shen L, Baldwin AS, Guan KL, Xiong Y, Ye D. Chen LL, et al. Among authors: chen x. Nat Cell Biol. 2022 Mar;24(3):353-363. doi: 10.1038/s41556-022-00853-8. Epub 2022 Mar 7. Nat Cell Biol. 2022. PMID: 35256775 Free PMC article.
Itaconate in host inflammation and defense.
Ye D, Wang P, Chen LL, Guan KL, Xiong Y. Ye D, et al. Trends Endocrinol Metab. 2024 Jul;35(7):586-606. doi: 10.1016/j.tem.2024.02.004. Epub 2024 Mar 5. Trends Endocrinol Metab. 2024. PMID: 38448252 Review.
Metabolite regulation of epigenetics in cancer.
Wang P, Chen LL, Xiong Y, Ye D. Wang P, et al. Cell Rep. 2024 Oct 22;43(10):114815. doi: 10.1016/j.celrep.2024.114815. Epub 2024 Oct 4. Cell Rep. 2024. PMID: 39368084 Free article. Review.
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