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Polytherapy with a combination of three repurposed drugs (PXT3003) down-regulates Pmp22 over-expression and improves myelination, axonal and functional parameters in models of CMT1A neuropathy.
Chumakov I, Milet A, Cholet N, Primas G, Boucard A, Pereira Y, Graudens E, Mandel J, Laffaire J, Foucquier J, Glibert F, Bertrand V, Nave KA, Sereda MW, Vial E, Guedj M, Hajj R, Nabirotchkin S, Cohen D. Chumakov I, et al. Among authors: laffaire j. Orphanet J Rare Dis. 2014 Dec 10;9:201. doi: 10.1186/s13023-014-0201-x. Orphanet J Rare Dis. 2014. PMID: 25491744 Free PMC article.
Synergistic PXT3003 therapy uncouples neuromuscular function from dysmyelination in male Charcot-Marie-Tooth disease type 1A (CMT1A) rats.
Prukop T, Wernick S, Boussicault L, Ewers D, Jäger K, Adam J, Winter L, Quintes S, Linhoff L, Barrantes-Freer A, Bartl M, Czesnik D, Zschüntzsch J, Schmidt J, Primas G, Laffaire J, Rinaudo P, Brureau A, Nabirotchkin S, Schwab MH, Nave KA, Hajj R, Cohen D, Sereda MW. Prukop T, et al. Among authors: laffaire j. J Neurosci Res. 2020 Oct;98(10):1933-1952. doi: 10.1002/jnr.24679. Epub 2020 Jun 26. J Neurosci Res. 2020. PMID: 32588471
Down syndrome gene dosage imbalance on cerebellum development.
Moldrich RX, Dauphinot L, Laffaire J, Rossier J, Potier MC. Moldrich RX, et al. Among authors: laffaire j. Prog Neurobiol. 2007 Jun;82(2):87-94. doi: 10.1016/j.pneurobio.2007.02.006. Epub 2007 Feb 23. Prog Neurobiol. 2007. PMID: 17408845 Review.
28 results