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The Redox State Regulates the Conformation of Rv2466c to Activate the Antitubercular Prodrug TP053.
Albesa-Jové D, Comino N, Tersa M, Mohorko E, Urresti S, Dainese E, Chiarelli LR, Pasca MR, Manganelli R, Makarov V, Riccardi G, Svergun DI, Glockshuber R, Guerin ME. Albesa-Jové D, et al. Among authors: riccardi g. J Biol Chem. 2015 Dec 25;290(52):31077-89. doi: 10.1074/jbc.M115.677039. Epub 2015 Nov 6. J Biol Chem. 2015. PMID: 26546681 Free PMC article.
Rv2466c mediates the activation of TP053 to kill replicating and non-replicating Mycobacterium tuberculosis.
Albesa-Jové D, Chiarelli LR, Makarov V, Pasca MR, Urresti S, Mori G, Salina E, Vocat A, Comino N, Mohorko E, Ryabova S, Pfieiffer B, Lopes Ribeiro AL, Rodrigo-Unzueta A, Tersa M, Zanoni G, Buroni S, Altmann KH, Hartkoorn RC, Glockshuber R, Cole ST, Riccardi G, Guerin ME. Albesa-Jové D, et al. Among authors: riccardi g. ACS Chem Biol. 2014 Jul 18;9(7):1567-75. doi: 10.1021/cb500149m. Epub 2014 Jun 13. ACS Chem Biol. 2014. PMID: 24877756 Free article.
Thiophenecarboxamide Derivatives Activated by EthA Kill Mycobacterium tuberculosis by Inhibiting the CTP Synthetase PyrG.
Mori G, Chiarelli LR, Esposito M, Makarov V, Bellinzoni M, Hartkoorn RC, Degiacomi G, Boldrin F, Ekins S, de Jesus Lopes Ribeiro AL, Marino LB, Centárová I, Svetlíková Z, Blaško J, Kazakova E, Lepioshkin A, Barilone N, Zanoni G, Porta A, Fondi M, Fani R, Baulard AR, Mikušová K, Alzari PM, Manganelli R, de Carvalho LP, Riccardi G, Cole ST, Pasca MR. Mori G, et al. Among authors: riccardi g. Chem Biol. 2015 Jul 23;22(7):917-27. doi: 10.1016/j.chembiol.2015.05.016. Epub 2015 Jun 18. Chem Biol. 2015. PMID: 26097035 Free PMC article.
New prodrugs against tuberculosis.
Mori G, Chiarelli LR, Riccardi G, Pasca MR. Mori G, et al. Among authors: riccardi g. Drug Discov Today. 2017 Mar;22(3):519-525. doi: 10.1016/j.drudis.2016.09.006. Epub 2016 Sep 17. Drug Discov Today. 2017. PMID: 27649942 Review.
New Insights into the Mechanism of Action of the Thienopyrimidine Antitubercular Prodrug TP053.
Chiarelli LR, Salina EG, Mori G, Azhikina T, Riabova O, Lepioshkin A, Grigorov A, Forbak M, Madacki J, Orena BS, Manfredi M, Gosetti F, Buzzi A, Degiacomi G, Sammartino JC, Marengo E, Korduláková J, Riccardi G, Mikušová K, Makarov V, Pasca MR. Chiarelli LR, et al. Among authors: riccardi g. ACS Infect Dis. 2020 Feb 14;6(2):313-323. doi: 10.1021/acsinfecdis.9b00388. Epub 2019 Dec 2. ACS Infect Dis. 2020. PMID: 31729215
Rv0579 Is Involved in the Resistance to the TP053 Antitubercular Prodrug.
Mori G, Orena BS, Chiarelli LR, Degiacomi G, Riabova O, Sammartino JC, Makarov V, Riccardi G, Pasca MR. Mori G, et al. Among authors: riccardi g. Front Microbiol. 2020 Feb 25;11:292. doi: 10.3389/fmicb.2020.00292. eCollection 2020. Front Microbiol. 2020. PMID: 32158439 Free PMC article.
Global analysis of the Mycobacterium tuberculosis Zur (FurB) regulon.
Maciag A, Dainese E, Rodriguez GM, Milano A, Provvedi R, Pasca MR, Smith I, Palù G, Riccardi G, Manganelli R. Maciag A, et al. Among authors: riccardi g. J Bacteriol. 2007 Feb;189(3):730-40. doi: 10.1128/JB.01190-06. Epub 2006 Nov 10. J Bacteriol. 2007. PMID: 17098899 Free PMC article.
588 results