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An Orally Bioavailable, Indole-3-glyoxylamide Based Series of Tubulin Polymerization Inhibitors Showing Tumor Growth Inhibition in a Mouse Xenograft Model of Head and Neck Cancer.
Colley HE, Muthana M, Danson SJ, Jackson LV, Brett ML, Harrison J, Coole SF, Mason DP, Jennings LR, Wong M, Tulasi V, Norman D, Lockey PM, Williams L, Dossetter AG, Griffen EJ, Thompson MJ. Colley HE, et al. Among authors: griffen ej. J Med Chem. 2015 Dec 10;58(23):9309-33. doi: 10.1021/acs.jmedchem.5b01312. Epub 2015 Dec 1. J Med Chem. 2015. PMID: 26580420 Free article.
Matched molecular pair analysis in drug discovery.
Dossetter AG, Griffen EJ, Leach AG. Dossetter AG, et al. Among authors: griffen ej. Drug Discov Today. 2013 Aug;18(15-16):724-31. doi: 10.1016/j.drudis.2013.03.003. Epub 2013 Apr 2. Drug Discov Today. 2013. PMID: 23557664 Review.
Chemists: AI Is Here; Unite To Get the Benefits.
Griffen EJ, Dossetter AG, Leach AG. Griffen EJ, et al. J Med Chem. 2020 Aug 27;63(16):8695-8704. doi: 10.1021/acs.jmedchem.0c00163. Epub 2020 Jun 11. J Med Chem. 2020. PMID: 32459965 Review.
DNA-dependent protein kinase (DNA-PK) inhibitors: structure-activity relationships for O-alkoxyphenylchromen-4-one probes of the ATP-binding domain.
Clapham KM, Bardos J, Finlay MR, Golding BT, Griffen EJ, Griffin RJ, Hardcastle IR, Menear KA, Ting A, Turner P, Young GL, Cano C. Clapham KM, et al. Among authors: griffen ej. Bioorg Med Chem Lett. 2011 Feb 1;21(3):966-70. doi: 10.1016/j.bmcl.2010.12.047. Epub 2010 Dec 13. Bioorg Med Chem Lett. 2011. PMID: 21216595
Matched molecular pairs as a medicinal chemistry tool.
Griffen E, Leach AG, Robb GR, Warner DJ. Griffen E, et al. J Med Chem. 2011 Nov 24;54(22):7739-50. doi: 10.1021/jm200452d. Epub 2011 Sep 22. J Med Chem. 2011. PMID: 21936582 No abstract available.
Learning Medicinal Chemistry Absorption, Distribution, Metabolism, Excretion, and Toxicity (ADMET) Rules from Cross-Company Matched Molecular Pairs Analysis (MMPA).
Kramer C, Ting A, Zheng H, Hert J, Schindler T, Stahl M, Robb G, Crawford JJ, Blaney J, Montague S, Leach AG, Dossetter AG, Griffen EJ. Kramer C, et al. Among authors: griffen ej. J Med Chem. 2018 Apr 26;61(8):3277-3292. doi: 10.1021/acs.jmedchem.7b00935. Epub 2017 Sep 28. J Med Chem. 2018. PMID: 28956609
19 results