Intracellular alkalinization by phosphate uptake via type III sodium-phosphate cotransporter participates in high-phosphate-induced mitochondrial oxidative stress and defective insulin secretion.
Nguyen TT, Quan X, Xu S, Das R, Cha SK, Kong ID, Shong M, Wollheim CB, Park KS.
Nguyen TT, et al. Among authors: xu s.
FASEB J. 2016 Dec;30(12):3979-3988. doi: 10.1096/fj.201600455RR. Epub 2016 Aug 26.
FASEB J. 2016.
PMID: 27565711
Type III sodium-phosphate cotransporters (NaP(i)s) are the predominant P(i) transporters expressed in insulin-secreting cells. Transcript and protein levels of sodium-dependent phosphate transporter 1 and 2 (PiT-1 and -2), isotypes of type III NaP(i), were up-regulated by …
Type III sodium-phosphate cotransporters (NaP(i)s) are the predominant P(i) transporters expressed in insulin-secreting cells. Transc …