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Enoyl-CoA hydratase-1 regulates mTOR signaling and apoptosis by sensing nutrients.
Zhang YK, Qu YY, Lin Y, Wu XH, Chen HZ, Wang X, Zhou KQ, Wei Y, Guo F, Yao CF, He XD, Liu LX, Yang C, Guan ZY, Wang SD, Zhao J, Liu DP, Zhao SM, Xu W. Zhang YK, et al. Among authors: yang c. Nat Commun. 2017 Sep 6;8(1):464. doi: 10.1038/s41467-017-00489-5. Nat Commun. 2017. PMID: 28878358 Free PMC article.
Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases.
Xu W, Yang H, Liu Y, Yang Y, Wang P, Kim SH, Ito S, Yang C, Wang P, Xiao MT, Liu LX, Jiang WQ, Liu J, Zhang JY, Wang B, Frye S, Zhang Y, Xu YH, Lei QY, Guan KL, Zhao SM, Xiong Y. Xu W, et al. Among authors: yang c, yang h, yang y. Cancer Cell. 2011 Jan 18;19(1):17-30. doi: 10.1016/j.ccr.2010.12.014. Cancer Cell. 2011. PMID: 21251613 Free PMC article.
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