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Pharmacologic inhibition of JAK-STAT signaling promotes hair growth.
Harel S, Higgins CA, Cerise JE, Dai Z, Chen JC, Clynes R, Christiano AM. Harel S, et al. Among authors: higgins ca. Sci Adv. 2015 Oct 23;1(9):e1500973. doi: 10.1126/sciadv.1500973. eCollection 2015 Oct. Sci Adv. 2015. PMID: 26601320 Free PMC article.
Building a microphysiological skin model from induced pluripotent stem cells.
Guo Z, Higgins CA, Gillette BM, Itoh M, Umegaki N, Gledhill K, Sia SK, Christiano AM. Guo Z, et al. Among authors: higgins ca. Stem Cell Res Ther. 2013;4 Suppl 1(Suppl 1):S2. doi: 10.1186/scrt363. Epub 2013 Dec 20. Stem Cell Res Ther. 2013. PMID: 24564920 Free PMC article. Review.
FGF5 is a crucial regulator of hair length in humans.
Higgins CA, Petukhova L, Harel S, Ho YY, Drill E, Shapiro L, Wajid M, Christiano AM. Higgins CA, et al. Proc Natl Acad Sci U S A. 2014 Jul 22;111(29):10648-53. doi: 10.1073/pnas.1402862111. Epub 2014 Jul 2. Proc Natl Acad Sci U S A. 2014. PMID: 24989505 Free PMC article.
Alopecia areata is driven by cytotoxic T lymphocytes and is reversed by JAK inhibition.
Xing L, Dai Z, Jabbari A, Cerise JE, Higgins CA, Gong W, de Jong A, Harel S, DeStefano GM, Rothman L, Singh P, Petukhova L, Mackay-Wiggan J, Christiano AM, Clynes R. Xing L, et al. Among authors: higgins ca. Nat Med. 2014 Sep;20(9):1043-9. doi: 10.1038/nm.3645. Epub 2014 Aug 17. Nat Med. 2014. PMID: 25129481 Free PMC article.
90 results