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Inhibiting WEE1 Selectively Kills Histone H3K36me3-Deficient Cancers by dNTP Starvation.
Pfister SX, Markkanen E, Jiang Y, Sarkar S, Woodcock M, Orlando G, Mavrommati I, Pai CC, Zalmas LP, Drobnitzky N, Dianov GL, Verrill C, Macaulay VM, Ying S, La Thangue NB, D'Angiolella V, Ryan AJ, Humphrey TC. Pfister SX, et al. Among authors: macaulay vm. Cancer Cell. 2015 Nov 9;28(5):557-568. doi: 10.1016/j.ccell.2015.09.015. Cancer Cell. 2015. PMID: 26602815 Free PMC article.
Dsh homolog DVL3 mediates resistance to IGFIR inhibition by regulating IGF-RAS signaling.
Gao S, Bajrami I, Verrill C, Kigozi A, Ouaret D, Aleksic T, Asher R, Han C, Allen P, Bailey D, Feller S, Kashima T, Athanasou N, Blay JY, Schmitz S, Machiels JP, Upile N, Jones TM, Thalmann G, Ashraf SQ, Wilding JL, Bodmer WF, Middleton MR, Ashworth A, Lord CJ, Macaulay VM. Gao S, et al. Among authors: macaulay vm. Cancer Res. 2014 Oct 15;74(20):5866-77. doi: 10.1158/0008-5472.CAN-14-0806. Epub 2014 Aug 28. Cancer Res. 2014. PMID: 25168481 Free article.
IGF-1R associates with adverse outcomes after radical radiotherapy for prostate cancer.
Aleksic T, Verrill C, Bryant RJ, Han C, Worrall AR, Brureau L, Larré S, Higgins GS, Fazal F, Sabbagh A, Haider S, Buffa FM, Cole D, Macaulay VM. Aleksic T, et al. Among authors: macaulay vm. Br J Cancer. 2017 Nov 21;117(11):1600-1606. doi: 10.1038/bjc.2017.337. Epub 2017 Oct 3. Br J Cancer. 2017. PMID: 28972962 Free PMC article.
Nuclear IGF1R Interacts with Regulatory Regions of Chromatin to Promote RNA Polymerase II Recruitment and Gene Expression Associated with Advanced Tumor Stage.
Aleksic T, Gray N, Wu X, Rieunier G, Osher E, Mills J, Verrill C, Bryant RJ, Han C, Hutchinson K, Lambert AG, Kumar R, Hamdy FC, Weyer-Czernilofsky U, Sanderson MP, Bogenrieder T, Taylor S, Macaulay VM. Aleksic T, et al. Among authors: macaulay vm. Cancer Res. 2018 Jul 1;78(13):3497-3509. doi: 10.1158/0008-5472.CAN-17-3498. Epub 2018 May 7. Cancer Res. 2018. PMID: 29735545 Free PMC article.
Targeting IGF Perturbs Global Replication through Ribonucleotide Reductase Dysfunction.
Rieunier G, Wu X, Harris LE, Mills JV, Nandakumar A, Colling L, Seraia E, Hatch SB, Ebner DV, Folkes LK, Weyer-Czernilofsky U, Bogenrieder T, Ryan AJ, Macaulay VM. Rieunier G, et al. Among authors: macaulay vm. Cancer Res. 2021 Apr 15;81(8):2128-2141. doi: 10.1158/0008-5472.CAN-20-2860. Epub 2021 Jan 28. Cancer Res. 2021. PMID: 33509941
CHK1 inhibition exacerbates replication stress induced by IGF blockade.
Wu X, Seraia E, Hatch SB, Wan X, Ebner DV, Aroldi F, Jiang Y, Ryan AJ, Bogenrieder T, Weyer-Czernilofsky U, Rieunier G, Macaulay VM. Wu X, et al. Among authors: macaulay vm. Oncogene. 2022 Jan;41(4):476-488. doi: 10.1038/s41388-021-02080-1. Epub 2021 Nov 12. Oncogene. 2022. PMID: 34773074 Free PMC article.
83 results