Steele JW - Search Results

1

Physiologically generated presenilin 1 lacking exon 8 fails to rescue brain PS1-/- phenotype and forms complexes with wildtype PS1 and nicastrin.

Brautigam H, Moreno CL, Steele JW, Bogush A, Dickstein DL, Kwok JB, Schofield PR, Thinakaran G, Mathews PM, Hof PR, Gandy S, Ehrlich ME. Brautigam H, et al. Among authors: steele jw. Sci Rep. 2015 Nov 26;5:17042. doi: 10.1038/srep17042. Sci Rep. 2015. PMID: 26608390 Free PMC article.

2

Proneurogenic Group II mGluR antagonist improves learning and reduces anxiety in Alzheimer Aβ oligomer mouse.

Kim SH, Steele JW, Lee SW, Clemenson GD, Carter TA, Treuner K, Gadient R, Wedel P, Glabe C, Barlow C, Ehrlich ME, Gage FH, Gandy S. Kim SH, et al. Among authors: steele jw. Mol Psychiatry. 2014 Nov;19(11):1235-42. doi: 10.1038/mp.2014.87. Epub 2014 Aug 12. Mol Psychiatry. 2014. PMID: 25113378 Free PMC article.

3

Diabetes-associated SorCS1 regulates Alzheimer's amyloid-beta metabolism: evidence for involvement of SorL1 and the retromer complex.

Lane RF, Raines SM, Steele JW, Ehrlich ME, Lah JA, Small SA, Tanzi RE, Attie AD, Gandy S. Lane RF, et al. Among authors: steele jw. J Neurosci. 2010 Sep 29;30(39):13110-5. doi: 10.1523/JNEUROSCI.3872-10.2010. J Neurosci. 2010. PMID: 20881129 Free PMC article.

4

The isotropic fractionator provides evidence for differential loss of hippocampal neurons in two mouse models of Alzheimer's disease.

Brautigam H, Steele JW, Westaway D, Fraser PE, St George-Hyslop PH, Gandy S, Hof PR, Dickstein DL. Brautigam H, et al. Among authors: steele jw. Mol Neurodegener. 2012 Nov 22;7:58. doi: 10.1186/1750-1326-7-58. Mol Neurodegener. 2012. PMID: 23173713 Free PMC article.

5

Latrepirdine (Dimebon®), a potential Alzheimer therapeutic, regulates autophagy and neuropathology in an Alzheimer mouse model.

Steele JW, Gandy S. Steele JW, et al. Autophagy. 2013 Apr;9(4):617-8. doi: 10.4161/auto.23487. Epub 2013 Feb 4. Autophagy. 2013. PMID: 23380933 Free PMC article.

6

Protein sorting motifs in the cytoplasmic tail of SorCS1 control generation of Alzheimer's amyloid-β peptide.

Lane RF, Steele JW, Cai D, Ehrlich ME, Attie AD, Gandy S. Lane RF, et al. Among authors: steele jw. J Neurosci. 2013 Apr 17;33(16):7099-107. doi: 10.1523/JNEUROSCI.5270-12.2013. J Neurosci. 2013. PMID: 23595767 Free PMC article.

7

Early fear memory defects are associated with altered synaptic plasticity and molecular architecture in the TgCRND8 Alzheimer's disease mouse model.

Steele JW, Brautigam H, Short JA, Sowa A, Shi M, Yadav A, Weaver CM, Westaway D, Fraser PE, St George-Hyslop PH, Gandy S, Hof PR, Dickstein DL. Steele JW, et al. J Comp Neurol. 2014 Jul 1;522(10):2319-35. doi: 10.1002/cne.23536. J Comp Neurol. 2014. PMID: 24415002 Free PMC article.

8

Evidence that small molecule enhancement of β-hexosaminidase activity corrects the behavioral phenotype in Dutch APP(E693Q) mice through reduction of ganglioside-bound Aβ.

Knight EM, Williams HN, Stevens AC, Kim SH, Kottwitz JC, Morant AD, Steele JW, Klein WL, Yanagisawa K, Boyd RE, Lockhart DJ, Sjoberg ER, Ehrlich ME, Wustman BA, Gandy S. Knight EM, et al. Among authors: steele jw. Mol Psychiatry. 2015 Feb;20(1):109-17. doi: 10.1038/mp.2014.135. Epub 2014 Oct 28. Mol Psychiatry. 2015. PMID: 25349165 Free PMC article.

9

Days to criterion as an indicator of toxicity associated with human Alzheimer amyloid-beta oligomers.

Gandy S, Simon AJ, Steele JW, Lublin AL, Lah JJ, Walker LC, Levey AI, Krafft GA, Levy E, Checler F, Glabe C, Bilker WB, Abel T, Schmeidler J, Ehrlich ME. Gandy S, et al. Among authors: steele jw. Ann Neurol. 2010 Aug;68(2):220-30. doi: 10.1002/ana.22052. Ann Neurol. 2010. PMID: 20641005 Free PMC article.

10

Characterization and molecular profiling of PSEN1 familial Alzheimer's disease iPSC-derived neural progenitors.

Sproul AA, Jacob S, Pre D, Kim SH, Nestor MW, Navarro-Sobrino M, Santa-Maria I, Zimmer M, Aubry S, Steele JW, Kahler DJ, Dranovsky A, Arancio O, Crary JF, Gandy S, Noggle SA. Sproul AA, et al. Among authors: steele jw. PLoS One. 2014 Jan 8;9(1):e84547. doi: 10.1371/journal.pone.0084547. eCollection 2014. PLoS One. 2014. PMID: 24416243 Free PMC article.

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