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Lyn deficiency affects B-cell maturation as well as survival.
Shahaf G, Gross AJ, Sternberg-Simon M, Kaplan D, DeFranco AL, Mehr R. Shahaf G, et al. Eur J Immunol. 2012 Feb;42(2):511-21. doi: 10.1002/eji.201141940. Epub 2011 Dec 14. Eur J Immunol. 2012. PMID: 22057631 Free PMC article.
Depletion of B cells rejuvenates the peripheral B-cell compartment but is insufficient to restore immune competence in aging.
Avivi I, Zisman-Rozen S, Naor S, Dai I, Benhamou D, Shahaf G, Tabibian-Keissar H, Rosenthal N, Rakovsky A, Hanna A, Shechter A, Peled E, Benyamini N, Dmitrukha E, Barshack I, Mehr R, Melamed D. Avivi I, et al. Aging Cell. 2019 Aug;18(4):e12959. doi: 10.1111/acel.12959. Epub 2019 May 6. Aging Cell. 2019. PMID: 31056853 Free PMC article. Clinical Trial.
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