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Synthetic lethal screen of an EGFR-centered network to improve targeted therapies.
Astsaturov I, Ratushny V, Sukhanova A, Einarson MB, Bagnyukova T, Zhou Y, Devarajan K, Silverman JS, Tikhmyanova N, Skobeleva N, Pecherskaya A, Nasto RE, Sharma C, Jablonski SA, Serebriiskii IG, Weiner LM, Golemis EA. Astsaturov I, et al. Among authors: golemis ea. Sci Signal. 2010 Sep 21;3(140):ra67. doi: 10.1126/scisignal.2001083. Sci Signal. 2010. PMID: 20858866 Free PMC article.
Targeting C4-demethylating genes in the cholesterol pathway sensitizes cancer cells to EGF receptor inhibitors via increased EGF receptor degradation.
Sukhanova A, Gorin A, Serebriiskii IG, Gabitova L, Zheng H, Restifo D, Egleston BL, Cunningham D, Bagnyukova T, Liu H, Nikonova A, Adams GP, Zhou Y, Yang DH, Mehra R, Burtness B, Cai KQ, Klein-Szanto A, Kratz LE, Kelley RI, Weiner LM, Herman GE, Golemis EA, Astsaturov I. Sukhanova A, et al. Among authors: golemis ea. Cancer Discov. 2013 Jan;3(1):96-111. doi: 10.1158/2159-8290.CD-12-0031. Epub 2012 Nov 2. Cancer Discov. 2013. PMID: 23125191 Free PMC article.
Aurora kinase A mediates epithelial ovarian cancer cell migration and adhesion.
Do TV, Xiao F, Bickel LE, Klein-Szanto AJ, Pathak HB, Hua X, Howe C, O'Brien SW, Maglaty M, Ecsedy JA, Litwin S, Golemis EA, Schilder RJ, Godwin AK, Connolly DC. Do TV, et al. Among authors: golemis ea. Oncogene. 2014 Jan 30;33(5):539-49. doi: 10.1038/onc.2012.632. Epub 2013 Jan 21. Oncogene. 2014. PMID: 23334327 Free PMC article.
Network analysis identifies an HSP90-central hub susceptible in ovarian cancer.
Liu H, Xiao F, Serebriiskii IG, O'Brien SW, Maglaty MA, Astsaturov I, Litwin S, Martin LP, Proia DA, Golemis EA, Connolly DC. Liu H, et al. Among authors: golemis ea. Clin Cancer Res. 2013 Sep 15;19(18):5053-67. doi: 10.1158/1078-0432.CCR-13-1115. Epub 2013 Jul 30. Clin Cancer Res. 2013. PMID: 23900136 Free PMC article.
234 results