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Page 1
Hif-1α and Hif-2α synergize to suppress AML development but are dispensable for disease maintenance.
Vukovic M, Guitart AV, Sepulveda C, Villacreces A, O'Duibhir E, Panagopoulou TI, Ivens A, Menendez-Gonzalez J, Iglesias JM, Allen L, Glykofrydis F, Subramani C, Armesilla-Diaz A, Post AE, Schaak K, Gezer D, So CW, Holyoake TL, Wood A, O'Carroll D, Ratcliffe PJ, Kranc KR. Vukovic M, et al. Among authors: holyoake tl. J Exp Med. 2015 Dec 14;212(13):2223-34. doi: 10.1084/jem.20150452. Epub 2015 Dec 7. J Exp Med. 2015. PMID: 26642852 Free PMC article.
Lineage tracing of Pf4-Cre marks hematopoietic stem cells and their progeny.
Calaminus SD, Guitart AV, Sinclair A, Schachtner H, Watson SP, Holyoake TL, Kranc KR, Machesky LM. Calaminus SD, et al. Among authors: holyoake tl. PLoS One. 2012;7(12):e51361. doi: 10.1371/journal.pone.0051361. Epub 2012 Dec 27. PLoS One. 2012. PMID: 23300543 Free PMC article.
Megakaryocytes assemble podosomes that degrade matrix and protrude through basement membrane.
Schachtner H, Calaminus SD, Sinclair A, Monypenny J, Blundell MP, Leon C, Holyoake TL, Thrasher AJ, Michie AM, Vukovic M, Gachet C, Jones GE, Thomas SG, Watson SP, Machesky LM. Schachtner H, et al. Among authors: holyoake tl. Blood. 2013 Mar 28;121(13):2542-52. doi: 10.1182/blood-2012-07-443457. Epub 2013 Jan 10. Blood. 2013. PMID: 23305739 Free article.
Hif-2α is not essential for cell-autonomous hematopoietic stem cell maintenance.
Guitart AV, Subramani C, Armesilla-Diaz A, Smith G, Sepulveda C, Gezer D, Vukovic M, Dunn K, Pollard P, Holyoake TL, Enver T, Ratcliffe PJ, Kranc KR. Guitart AV, et al. Among authors: holyoake tl. Blood. 2013 Sep 5;122(10):1741-5. doi: 10.1182/blood-2013-02-484923. Epub 2013 Jul 26. Blood. 2013. PMID: 23894152 Free article.
Adult hematopoietic stem cells lacking Hif-1α self-renew normally.
Vukovic M, Sepulveda C, Subramani C, Guitart AV, Mohr J, Allen L, Panagopoulou TI, Paris J, Lawson H, Villacreces A, Armesilla-Diaz A, Gezer D, Holyoake TL, Ratcliffe PJ, Kranc KR. Vukovic M, et al. Among authors: holyoake tl. Blood. 2016 Jun 9;127(23):2841-6. doi: 10.1182/blood-2015-10-677138. Epub 2016 Apr 8. Blood. 2016. PMID: 27060169 Free PMC article.
CXCR2 and CXCL4 regulate survival and self-renewal of hematopoietic stem/progenitor cells.
Sinclair A, Park L, Shah M, Drotar M, Calaminus S, Hopcroft LE, Kinstrie R, Guitart AV, Dunn K, Abraham SA, Sansom O, Michie AM, Machesky L, Kranc KR, Graham GJ, Pellicano F, Holyoake TL. Sinclair A, et al. Among authors: holyoake tl. Blood. 2016 Jul 21;128(3):371-83. doi: 10.1182/blood-2015-08-661785. Epub 2016 May 24. Blood. 2016. PMID: 27222476 Free PMC article.
hsa-mir183/EGR1-mediated regulation of E2F1 is required for CML stem/progenitor cell survival.
Pellicano F, Park L, Hopcroft LEM, Shah MM, Jackson L, Scott MT, Clarke CJ, Sinclair A, Abraham SA, Hair A, Helgason GV, Aspinall-O'Dea M, Bhatia R, Leone G, Kranc KR, Whetton AD, Holyoake TL. Pellicano F, et al. Among authors: holyoake tl. Blood. 2018 Apr 5;131(14):1532-1544. doi: 10.1182/blood-2017-05-783845. Epub 2018 Feb 5. Blood. 2018. PMID: 29437554 Free PMC article.
Combined BCR-ABL inhibition with lentiviral-delivered shRNA and dasatinib augments induction of apoptosis in Philadelphia-positive cells.
Myssina S, Helgason GV, Serrels A, Jørgensen HG, Bhatia R, Modi H, Baird JW, Mountford JC, Hamilton A, Schemionek M, Koschmieder S, Brunton VG, Holyoake TL. Myssina S, et al. Among authors: holyoake tl. Exp Hematol. 2009 Feb;37(2):206-14. doi: 10.1016/j.exphem.2008.10.013. Epub 2008 Dec 18. Exp Hematol. 2009. PMID: 19100678 Free article.
216 results