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NLRP12 interacts with NLRP3 to block the activation of the human NLRP3 inflammasome.
Coombs JR, Zamoshnikova A, Holley CL, Maddugoda MP, Teo DET, Chauvin C, Poulin LF, Vitak N, Ross CM, Mellacheruvu M, Coll RC, Heinz LX, Burgener SS, Emming S, Chamaillard M, Boucher D, Schroder K. Coombs JR, et al. Among authors: heinz lx. Sci Signal. 2024 Jan 23;17(820):eabg8145. doi: 10.1126/scisignal.abg8145. Epub 2024 Jan 23. Sci Signal. 2024. PMID: 38261657
SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1.
Rebsamen M, Pochini L, Stasyk T, de Araújo ME, Galluccio M, Kandasamy RK, Snijder B, Fauster A, Rudashevskaya EL, Bruckner M, Scorzoni S, Filipek PA, Huber KV, Bigenzahn JW, Heinz LX, Kraft C, Bennett KL, Indiveri C, Huber LA, Superti-Furga G. Rebsamen M, et al. Among authors: heinz lx. Nature. 2015 Mar 26;519(7544):477-81. doi: 10.1038/nature14107. Epub 2015 Jan 7. Nature. 2015. PMID: 25561175 Free PMC article.
Coincidental loss of DOCK8 function in NLRP10-deficient and C3H/HeJ mice results in defective dendritic cell migration.
Krishnaswamy JK, Singh A, Gowthaman U, Wu R, Gorrepati P, Sales Nascimento M, Gallman A, Liu D, Rhebergen AM, Calabro S, Xu L, Ranney P, Srivastava A, Ranson M, Gorham JD, McCaw Z, Kleeberger SR, Heinz LX, Müller AC, Bennett KL, Superti-Furga G, Henao-Mejia J, Sutterwala FS, Williams A, Flavell RA, Eisenbarth SC. Krishnaswamy JK, et al. Among authors: heinz lx. Proc Natl Acad Sci U S A. 2015 Mar 10;112(10):3056-61. doi: 10.1073/pnas.1501554112. Epub 2015 Feb 23. Proc Natl Acad Sci U S A. 2015. PMID: 25713392 Free PMC article.
The Lipid-Modifying Enzyme SMPDL3B Negatively Regulates Innate Immunity.
Heinz LX, Baumann CL, Köberlin MS, Snijder B, Gawish R, Shui G, Sharif O, Aspalter IM, Müller AC, Kandasamy RK, Breitwieser FP, Pichlmair A, Bruckner M, Rebsamen M, Blüml S, Karonitsch T, Fauster A, Colinge J, Bennett KL, Knapp S, Wenk MR, Superti-Furga G. Heinz LX, et al. Cell Rep. 2015 Jun 30;11(12):1919-28. doi: 10.1016/j.celrep.2015.05.006. Epub 2015 Jun 18. Cell Rep. 2015. PMID: 26095358 Free PMC article.
Functional crosstalk between membrane lipids and TLR biology.
Köberlin MS, Heinz LX, Superti-Furga G. Köberlin MS, et al. Among authors: heinz lx. Curr Opin Cell Biol. 2016 Apr;39:28-36. doi: 10.1016/j.ceb.2016.01.010. Epub 2016 Feb 16. Curr Opin Cell Biol. 2016. PMID: 26895312 Free article. Review.
Crystal structure of mammalian acid sphingomyelinase.
Gorelik A, Illes K, Heinz LX, Superti-Furga G, Nagar B. Gorelik A, et al. Among authors: heinz lx. Nat Commun. 2016 Jul 20;7:12196. doi: 10.1038/ncomms12196. Nat Commun. 2016. PMID: 27435900 Free PMC article.
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