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Glucose-derived spiro-isoxazolines are anti-hyperglycemic agents against type 2 diabetes through glycogen phosphorylase inhibition.
Goyard D, Kónya B, Chajistamatiou AS, Chrysina ED, Leroy J, Balzarin S, Tournier M, Tousch D, Petit P, Duret C, Maurel P, Somsák L, Docsa T, Gergely P, Praly JP, Azay-Milhau J, Vidal S. Goyard D, et al. Among authors: balzarin s. Eur J Med Chem. 2016 Jan 27;108:444-454. doi: 10.1016/j.ejmech.2015.12.004. Epub 2015 Dec 10. Eur J Med Chem. 2016. PMID: 26708111
Glucose-based spiro-oxathiazoles as in vivo anti-hyperglycemic agents through glycogen phosphorylase inhibition.
Goyard D, Kónya B, Czifrák K, Larini P, Demontrond F, Leroy J, Balzarin S, Tournier M, Tousch D, Petit P, Duret C, Maurel P, Docsa T, Gergely P, Somsák L, Praly JP, Azay-Milhau J, Vidal S. Goyard D, et al. Among authors: balzarin s. Org Biomol Chem. 2020 Feb 7;18(5):931-940. doi: 10.1039/c9ob01190k. Epub 2020 Jan 10. Org Biomol Chem. 2020. PMID: 31922157
Identification of Small Inhibitory Molecules Targeting the Bfl-1 Anti-Apoptotic Protein That Alleviates Resistance to ABT-737.
Mathieu AL, Sperandio O, Pottiez V, Balzarin S, Herlédan A, Elkaïm JO, Fogeron ML, Piveteau C, Dassonneville S, Deprez B, Villoutreix BO, Bonnefoy N, Leroux F. Mathieu AL, et al. Among authors: balzarin s. J Biomol Screen. 2014 Aug;19(7):1035-46. doi: 10.1177/1087057114534070. Epub 2014 May 8. J Biomol Screen. 2014. PMID: 24809353