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Linking HSP90 target occupancy to HSP70 induction and efficacy in mouse brain.
Thirstrup K, Sotty F, Montezinho LC, Badolo L, Thougaard A, Kristjánsson M, Jensen T, Watson S, Nielsen SM. Thirstrup K, et al. Among authors: thougaard a. Pharmacol Res. 2016 Feb;104:197-205. doi: 10.1016/j.phrs.2015.12.028. Epub 2015 Dec 29. Pharmacol Res. 2016. PMID: 26731018
Synthesis and Characterization of the Novel Rodent-Active and CNS-Penetrant P2X7 Receptor Antagonist Lu AF27139.
Hopper AT, Juhl M, Hornberg J, Badolo L, Kilburn JP, Thougaard A, Smagin G, Song D, Calice L, Menon V, Dale E, Zhang H, Cajina M, Nattini ME, Gandhi A, Grenon M, Jones K, Khayrullina T, Chandrasena G, Thomsen C, Zorn SH, Brodbeck R, Poda SB, Staal R, Möller T. Hopper AT, et al. Among authors: thougaard a. J Med Chem. 2021 Apr 22;64(8):4891-4902. doi: 10.1021/acs.jmedchem.0c02249. Epub 2021 Apr 6. J Med Chem. 2021. PMID: 33822617
Nonclinical safety evaluation, pharmacokinetics, and target engagement of Lu AF82422, a monoclonal IgG1 antibody against alpha-synuclein in development for treatment of synucleinopathies.
Fjord-Larsen L, Thougaard A, Wegener KM, Christiansen J, Larsen F, Schrøder-Hansen LM, Kaarde M, Ditlevsen DK. Fjord-Larsen L, et al. Among authors: thougaard a. MAbs. 2021 Jan-Dec;13(1):1994690. doi: 10.1080/19420862.2021.1994690. MAbs. 2021. PMID: 34709986 Free PMC article.
31 results