Ablation of the microRNA-17-92 cluster in neural stem cells diminishes adult hippocampal neurogenesis and cognitive function.
Pan WL, Chopp M, Fan B, Zhang R, Wang X, Hu J, Zhang XM, Zhang ZG, Liu XS.
Pan WL, et al.
FASEB J. 2019 Apr;33(4):5257-5267. doi: 10.1096/fj.201801019R. Epub 2019 Jan 22.
FASEB J. 2019.
PMID: 30668139
Free PMC article.
Compared with wild-type mice, ablation of the miR-17-92 cluster significantly reduced the number of proliferating NSCs and neuroblasts and neuronal differentiation in the dentate gyrus (DG) of the hippocampus and significantly impaired hippocampal-dependent learning and memory, a …
Compared with wild-type mice, ablation of the miR-17-92 cluster significantly reduced the number of proliferating NSCs and neuroblasts and n …