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Determination of the substrate repertoire of ADAMTS2, 3, and 14 significantly broadens their functions and identifies extracellular matrix organization and TGF-β signaling as primary targets.
Bekhouche M, Leduc C, Dupont L, Janssen L, Delolme F, Vadon-Le Goff S, Smargiasso N, Baiwir D, Mazzucchelli G, Zanella-Cleon I, Dubail J, De Pauw E, Nusgens B, Hulmes DJ, Moali C, Colige A. Bekhouche M, et al. Among authors: moali c. FASEB J. 2016 May;30(5):1741-56. doi: 10.1096/fj.15-279869. Epub 2016 Jan 6. FASEB J. 2016. PMID: 26740262 Free article.
This work shows that the activities of the pNPs extend far beyond the classically reported processing of the aminopropeptide of fibrillar collagens and that they should now be considered as multilevel regulators of matrix deposition and remodeling.-Bekhouche, M., Leduc, C. …
This work shows that the activities of the pNPs extend far beyond the classically reported processing of the aminopropeptide of fibrillar co …
Substrate-specific modulation of a multisubstrate proteinase. C-terminal processing of fibrillar procollagens is the only BMP-1-dependent activity to be enhanced by PCPE-1.
Moali C, Font B, Ruggiero F, Eichenberger D, Rousselle P, François V, Oldberg A, Bruckner-Tuderman L, Hulmes DJ. Moali C, et al. J Biol Chem. 2005 Jun 24;280(25):24188-94. doi: 10.1074/jbc.M501486200. Epub 2005 Apr 15. J Biol Chem. 2005. PMID: 15834133 Free article.
These and previous results (Ricard-Blum, S., Bernocco, S., Font, B., Moali, C., Eichenberger, D., Farjanel, J., Burchardt, E. R., van der Rest, M., Kessler, E., and Hulmes, D. ...V., Ruggiero, F., Ricard-Blum, S., Ebel, C., Geourjon, C., Deleage, G., F …
These and previous results (Ricard-Blum, S., Bernocco, S., Font, B., Moali, C., Eichenberger, D., Farjanel, J., Burchardt, E. …
Insights into how CUB domains can exert specific functions while sharing a common fold: conserved and specific features of the CUB1 domain contribute to the molecular basis of procollagen C-proteinase enhancer-1 activity.
Blanc G, Font B, Eichenberger D, Moreau C, Ricard-Blum S, Hulmes DJ, Moali C. Blanc G, et al. Among authors: moali c. J Biol Chem. 2007 Jun 8;282(23):16924-33. doi: 10.1074/jbc.M701610200. Epub 2007 Apr 19. J Biol Chem. 2007. PMID: 17446170 Free article.
Sizzled is unique among secreted frizzled-related proteins for its ability to specifically inhibit bone morphogenetic protein-1 (BMP-1)/tolloid-like proteinases.
Bijakowski C, Vadon-Le Goff S, Delolme F, Bourhis JM, Lécorché P, Ruggiero F, Becker-Pauly C, Yiallouros I, Stöcker W, Dive V, Hulmes DJ, Moali C. Bijakowski C, et al. Among authors: moali c. J Biol Chem. 2012 Sep 28;287(40):33581-93. doi: 10.1074/jbc.M112.380816. Epub 2012 Jul 23. J Biol Chem. 2012. PMID: 22825851 Free PMC article.
48 results