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Page 1
TIGIT Marks Exhausted T Cells, Correlates with Disease Progression, and Serves as a Target for Immune Restoration in HIV and SIV Infection.
Chew GM, Fujita T, Webb GM, Burwitz BJ, Wu HL, Reed JS, Hammond KB, Clayton KL, Ishii N, Abdel-Mohsen M, Liegler T, Mitchell BI, Hecht FM, Ostrowski M, Shikuma CM, Hansen SG, Maurer M, Korman AJ, Deeks SG, Sacha JB, Ndhlovu LC. Chew GM, et al. PLoS Pathog. 2016 Jan 7;12(1):e1005349. doi: 10.1371/journal.ppat.1005349. eCollection 2016 Jan. PLoS Pathog. 2016. PMID: 26741490 Free PMC article.
Expansion of dysfunctional Tim-3-expressing effector memory CD8+ T cells during simian immunodeficiency virus infection in rhesus macaques.
Fujita T, Burwitz BJ, Chew GM, Reed JS, Pathak R, Seger E, Clayton KL, Rini JM, Ostrowski MA, Ishii N, Kuroda MJ, Hansen SG, Sacha JB, Ndhlovu LC. Fujita T, et al. Among authors: chew gm. J Immunol. 2014 Dec 1;193(11):5576-83. doi: 10.4049/jimmunol.1400961. Epub 2014 Oct 27. J Immunol. 2014. PMID: 25348621 Free PMC article.
Soluble T cell immunoglobulin mucin domain 3 is shed from CD8+ T cells by the sheddase ADAM10, is increased in plasma during untreated HIV infection, and correlates with HIV disease progression.
Clayton KL, Douglas-Vail MB, Nur-ur Rahman AK, Medcalf KE, Xie IY, Chew GM, Tandon R, Lanteri MC, Norris PJ, Deeks SG, Ndhlovu LC, Ostrowski MA. Clayton KL, et al. Among authors: chew gm. J Virol. 2015 Apr;89(7):3723-36. doi: 10.1128/JVI.00006-15. Epub 2015 Jan 21. J Virol. 2015. PMID: 25609823 Free PMC article.
Human Galectin-9 Is a Potent Mediator of HIV Transcription and Reactivation.
Abdel-Mohsen M, Chavez L, Tandon R, Chew GM, Deng X, Danesh A, Keating S, Lanteri M, Samuels ML, Hoh R, Sacha JB, Norris PJ, Niki T, Shikuma CM, Hirashima M, Deeks SG, Ndhlovu LC, Pillai SK. Abdel-Mohsen M, et al. Among authors: chew gm. PLoS Pathog. 2016 Jun 2;12(6):e1005677. doi: 10.1371/journal.ppat.1005677. eCollection 2016 Jun. PLoS Pathog. 2016. PMID: 27253379 Free PMC article.
Galectin-9 is rapidly released during acute HIV-1 infection and remains sustained at high levels despite viral suppression even in elite controllers.
Tandon R, Chew GM, Byron MM, Borrow P, Niki T, Hirashima M, Barbour JD, Norris PJ, Lanteri MC, Martin JN, Deeks SG, Ndhlovu LC. Tandon R, et al. Among authors: chew gm. AIDS Res Hum Retroviruses. 2014 Jul;30(7):654-64. doi: 10.1089/AID.2014.0004. Epub 2014 May 28. AIDS Res Hum Retroviruses. 2014. PMID: 24786365 Free PMC article.
Red blood cell distribution width as an easily measurable biomarker of persistent inflammation and T cell dysregulation in antiretrovirally treated HIV-infected adults.
Zhang Z, Chew GM, Shikuma CM, Gangcuangco LMA, Souza SA, Shiramizu B, Nakamoto BK, Gong T, Mannem SR, Mitchell BI, Kallianpur KJ, Ndhlovu LC, Chow DC. Zhang Z, et al. Among authors: chew gm. HIV Clin Trials. 2018 Oct;19(5):172-176. doi: 10.1080/15284336.2018.1514821. Epub 2018 Nov 13. HIV Clin Trials. 2018. PMID: 30422099 Free PMC article.
Siglec-9 defines and restrains a natural killer subpopulation highly cytotoxic to HIV-infected cells.
Adeniji OS, Kuri-Cervantes L, Yu C, Xu Z, Ho M, Chew GM, Shikuma C, Tomescu C, George AF, Roan NR, Ndhlovu LC, Liu Q, Muthumani K, Weiner DB, Betts MR, Xiao H, Abdel-Mohsen M. Adeniji OS, et al. Among authors: chew gm. PLoS Pathog. 2021 Nov 11;17(11):e1010034. doi: 10.1371/journal.ppat.1010034. eCollection 2021 Nov. PLoS Pathog. 2021. PMID: 34762717 Free PMC article.
Mitochondrial oxidative phosphorylation in peripheral blood mononuclear cells is decreased in chronic HIV and correlates with immune dysregulation.
Gangcuangco LMA, Mitchell BI, Siriwardhana C, Kohorn LB, Chew GM, Bowler S, Kallianpur KJ, Chow DC, Ndhlovu LC, Gerschenson M, Shikuma CM. Gangcuangco LMA, et al. Among authors: chew gm. PLoS One. 2020 Apr 30;15(4):e0231761. doi: 10.1371/journal.pone.0231761. eCollection 2020. PLoS One. 2020. PMID: 32353005 Free PMC article.
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