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Misassembly of full-length Disrupted-in-Schizophrenia 1 protein is linked to altered dopamine homeostasis and behavioral deficits.
Trossbach SV, Bader V, Hecher L, Pum ME, Masoud ST, Prikulis I, Schäble S, de Souza Silva MA, Su P, Boulat B, Chwiesko C, Poschmann G, Stühler K, Lohr KM, Stout KA, Oskamp A, Godsave SF, Müller-Schiffmann A, Bilzer T, Steiner H, Peters PJ, Bauer A, Sauvage M, Ramsey AJ, Miller GW, Liu F, Seeman P, Brandon NJ, Huston JP, Korth C. Trossbach SV, et al. Among authors: schable s. Mol Psychiatry. 2016 Nov;21(11):1561-1572. doi: 10.1038/mp.2015.194. Epub 2016 Jan 12. Mol Psychiatry. 2016. PMID: 26754951 Free PMC article.
The NK3 receptor agonist senktide ameliorates scopolamine-induced deficits in memory for object, place and temporal order.
Schäble S, Huston JP, Barros M, Tomaz C, de Souza Silva MA. Schäble S, et al. Neurobiol Learn Mem. 2012 Feb;97(2):235-40. doi: 10.1016/j.nlm.2011.12.007. Epub 2011 Dec 22. Neurobiol Learn Mem. 2012. PMID: 22209911
Senktide, a potent neurokinin-3 receptor (NK3-R) agonist, increases acetylcholine (ACh) release in the striatum, the prefrontal cortex (Schable et al., 2011), the amygdala and hippocampus, presumably via postsynaptic mechanisms. ...Administration of senktide reversed the s …
Senktide, a potent neurokinin-3 receptor (NK3-R) agonist, increases acetylcholine (ACh) release in the striatum, the prefrontal cortex (S …
Neurokinin3 receptor as a target to predict and improve learning and memory in the aged organism.
de Souza Silva MA, Lenz B, Rotter A, Biermann T, Peters O, Ramirez A, Jessen F, Maier W, Hüll M, Schröder J, Frölich L, Teipel S, Gruber O, Kornhuber J, Huston JP, Müller CP, Schäble S. de Souza Silva MA, et al. Among authors: schable s. Proc Natl Acad Sci U S A. 2013 Sep 10;110(37):15097-102. doi: 10.1073/pnas.1306884110. Epub 2013 Aug 27. Proc Natl Acad Sci U S A. 2013. PMID: 23983264 Free PMC article.
Amyloid-β dimers in the absence of plaque pathology impair learning and synaptic plasticity.
Müller-Schiffmann A, Herring A, Abdel-Hafiz L, Chepkova AN, Schäble S, Wedel D, Horn AH, Sticht H, de Souza Silva MA, Gottmann K, Sergeeva OA, Huston JP, Keyvani K, Korth C. Müller-Schiffmann A, et al. Among authors: schable s. Brain. 2016 Feb;139(Pt 2):509-25. doi: 10.1093/brain/awv355. Epub 2015 Dec 10. Brain. 2016. PMID: 26657517
25 results