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Discovery of aminoquinazoline derivatives as human A(2A) adenosine receptor antagonists.
Zhou G, Aslanian R, Gallo G, Khan T, Kuang R, Purakkattle B, De Ruiz M, Stamford A, Ting P, Wu H, Wang H, Xiao D, Yu T, Zhang Y, Mullins D, Hodgson R. Zhou G, et al. Among authors: zhang y. Bioorg Med Chem Lett. 2016 Feb 15;26(4):1348-54. doi: 10.1016/j.bmcl.2015.11.048. Epub 2015 Dec 1. Bioorg Med Chem Lett. 2016. PMID: 26781932
SCH 1473759, a novel Aurora inhibitor, demonstrates enhanced anti-tumor activity in combination with taxanes and KSP inhibitors.
Basso AD, Liu M, Gray K, Tevar S, Lee S, Liang L, Ponery A, Smith EB, Monsma FJ Jr, Yu T, Zhang Y, Kerekes AD, Esposite S, Xiao Y, Tagat JR, Hicklin DJ, Kirschmeier P. Basso AD, et al. Among authors: zhang y. Cancer Chemother Pharmacol. 2011 Oct;68(4):923-33. doi: 10.1007/s00280-011-1568-1. Epub 2011 Feb 5. Cancer Chemother Pharmacol. 2011. PMID: 21298383
Discovery of a Potent, Injectable Inhibitor of Aurora Kinases Based on the Imidazo-[1,2-a]-Pyrazine Core.
Yu T, Tagat JR, Kerekes AD, Doll RJ, Zhang Y, Xiao Y, Esposite S, Belanger DB, Curran PJ, Mandal AK, Siddiqui MA, Shih NY, Basso AD, Liu M, Gray K, Tevar S, Jones J, Lee S, Liang L, Ponery S, Smith EB, Hruza A, Voigt J, Ramanathan L, Prosise W, Hu M. Yu T, et al. Among authors: zhang y. ACS Med Chem Lett. 2010 Jun 7;1(5):214-8. doi: 10.1021/ml100063w. eCollection 2010 Aug 12. ACS Med Chem Lett. 2010. PMID: 24900197 Free PMC article.
Discovery of a highly potent orally bioavailable imidazo-[1, 2-a]pyrazine Aurora inhibitor.
Yu T, Zhang Y, Kerekes AD, Tagat JR, Doll RJ, Xiao Y, Esposite S, Hruza A, Belanger DB, Voss M, Rainka MP, Basso A, Liu M, Liang L, Sui N, Prelusky D, Rindgen D, Zhang L. Yu T, et al. Among authors: zhang l, zhang y. Bioorg Med Chem Lett. 2018 May 1;28(8):1397-1403. doi: 10.1016/j.bmcl.2018.02.037. Epub 2018 Feb 23. Bioorg Med Chem Lett. 2018. PMID: 29545102
Unexpected Propargylic Retro-Brook Rearrangements in Alkynes.
Wang X, Gao Q, Buevich AV, Yasuda N, Zhang Y, Yang RS, Zhang LK, Martin GE, Williamson RT. Wang X, et al. Among authors: zhang lk, zhang y. J Org Chem. 2019 Aug 16;84(16):10024-10031. doi: 10.1021/acs.joc.9b01190. Epub 2019 Jul 22. J Org Chem. 2019. PMID: 31283876
Highly Diastereoselective Access to Densely Functionalized Piperidine Cores of Influenza Endonuclease Inhibitors via a Metal-Free SN1 Approach.
Zhang Y, Sun C, Guo L, Zhao K, Bennett F, Lam YH, Gao Q, Ruhl KE, Pirnot MT, Emmert MH, Hollenstein K, Eddins MJ, Su HP, Shao G, Song C, Lo MM, Peng F, Qi J, Crowley BM, McCauley JA, Price IR. Zhang Y, et al. J Org Chem. 2025 Jan 17;90(2):1175-1179. doi: 10.1021/acs.joc.4c02379. Epub 2025 Jan 2. J Org Chem. 2025. PMID: 39745425
Glycosylation of Nucleosides.
Zhang Y, Knapp S. Zhang Y, et al. J Org Chem. 2016 Mar 18;81(6):2228-42. doi: 10.1021/acs.joc.5b02852. Epub 2016 Mar 4. J Org Chem. 2016. PMID: 26938666
AI comes to the Nobel Prize and drug discovery.
Zhou Y, Zhang Y, Zhang Z, Zhou Z, Zhu F. Zhou Y, et al. Among authors: zhang y. J Pharm Anal. 2024 Nov;14(11):101160. doi: 10.1016/j.jpha.2024.101160. Epub 2024 Dec 21. J Pharm Anal. 2024. PMID: 39850961 Free PMC article. No abstract available.
262,609 results
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